Bronchial provocation challenges may be useful for establishing a definitive diagnosis of asthma in individuals with compatible symptoms and normal pulmonary function test results.
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Background: Smoking is a growing concern among young women. However, the pulmonary effects of smoking in young female smokers in...
Added 6 years ago
Direct oral anticoagulants (DOACs) are a new class of anticoagulants that directly inhibit either thrombin or factor Xa in the coagulation cascade. They are being increasingly used instead of warfarin or other vitamin K antagonists (VKAs).
Added 4 hours ago
Background: Andexanet alfa is a modified recombinant inactive form of human factor Xa developed for reversal of factor Xa inhibitors.
Added 5 hours ago
Evaluation of the Use of Low-Dose 4-Factor Prothrombin Complex Concentrate in the Reversal of Direct Oral Anticoagulants in Bleeding Patients.
Objective: This study investigated the percentage of patients who achieved hemostasis with 4-factor prothrombin complex concentrate (4-factor PCC) 35 U/kg.
Added 10 hours ago
Novavax, Inc.announced results from Prepare, a global Phase III clinical trial using ResVax an aluminum adjuvanted respiratory syncytial virus (RSV)...
Added 20 days ago
FDA gives 510(k) approval for the Accula RSV test for diagnosing respiratory syncytial virus.- Mesa Biotech.
Mesa Biotech announced that it received 510(k) clearance and Clinical Laboratory Improvements Amendments (CLIA) waiver from the FDA for its...
Added 3 months ago
AstraZeneca has agreed to sell US rights to Synagis (palivizumab) used for the prevention of serious lower respiratory tract infection...
Added 4 months ago
Suptavumab (REGN 2222) fails Phase III trial to prevent medically-attended RSV infections in infants.- Regeneron.
Regeneron Pharmaceuticals, Inc.announced that a Phase III study evaluating suptavumab (REGN 2222), an antibody to respiratory syncytial virus (RSV), did...
Added 1 year ago
Merck KGaA and Pfizer Inc. have announced the discontinuation of the ongoing Phase III JAVELIN Ovarian PARP 100 study evaluating...
Added 10 hours ago
A Study in Patients With Acute Major Bleeding to Evaluate the Ability of Andexanet Alfa to Reverse the Anticoagulation Effect of Direct and Indirect Oral Anticoagulants (Extension Study)
The purpose of this study is to evaluate the hemostatic efficacy of andexanet alfa in patients receiving a factor Xa inhibitor who are experiencing an acute major bleed. The safety of andexanet will also be studied.
Added 5 hours ago
Effects of Long-Term Administration of Human Albumin in Subjects With Decompensated Cirrhosis and Ascites (PRECIOSA)
This is a phase 3, multicenter, randomized, controlled, parallel-group, and open-label clinical study to evaluate the efficacy of standard medical treatment (SMT) + Albutein 20% administration versus SMT alone in subjects with...
Added 3 days ago
A Study of the Efficacy and Safety of Relacorilant in Patients With Endogenous Cushing Syndrome (GRACE)
This is a Phase 3, double-blind, placebo-controlled, randomized-withdrawal study to assess the safety and efficacy of relacorilant in patients with endogenous Cushing syndrome and concurrent 1) Type 2 diabetes mellitus/impaired...
Added 10 days ago
A Study to Assess the Safety and Efficacy of Levoketoconazole in the Treatment of Endogenous Cushing's Syndrome.
This is a double-blind, randomized, placebo-controlled withdrawal and rescue/restoration study in subjects with endogenous CS previously treated with single-arm, open-label levoketoconazole that will assess efficacy, safety, tolerability, and...
Added 10 days ago
Repetitive levosimendan infusions for patients with advanced chronic heart failure (LeoDOR) A randomised, double-blind, placebo-controlled multicentre study with parallel group design.
Added 1 month ago
This guideline covers diagnosing and managing bronchiolitis in children. It aims to help healthcare professionals diagnose bronchiolitis and identify if children should be cared for at home or in hospital.
Added 3 years ago
It provides evidence-based recommendations for the most common management questions occurring in routine clinical practice in the management of adult patients with LRTI.
Added 7 years ago