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Added 4 years ago Drug news

Pabal (carbetocin) new formulation approved through EU Mutual Recognition Procedure for prevention of uterine atony and postpartum haemorrhage - Ferring

Ferring announced that its new room-temperature-stable formulation of Pabal (carbetocin) for intravenous (IV) administration has been approved through the EU...

Added 4 years ago Drug news

FDA approves additional indication for Evarrest (fibrin sealant patch) for bleeding control during liver surgery-Ethicon

The FDA has approved an additional indication for Ethicon's Evarrest (fibrin sealant patch), as an adjunct to hemostasis for control...

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Learning Zones

An Learning Zone (LZ) is an area of the site dedicated to providing detailed self-directed medical education about a disease, condition or procedure.

Fibrinogen Deficiency in Bleeding

Fibrinogen Deficiency in Bleeding

Fibrinogen is important for blood clot formation and breakdown. It is the first coagulant factor to be reduced to critical levels during massive trauma, cardiac surgery and postpartum haemorrhage that involve excessive bleeding. Persistent fibrinogen deficiency can lead to bleeding complications and an increased risk in mortality. This learning zone looks at both congenital and acquired fibrinogen deficiencies including indications and techniques for diagnosis, trigger level for treatment and treatment options.

Oral Anticoagulation Reversal

Oral Anticoagulation Reversal

Experts discuss the use of non-vitamin K oral anticoagulants in the treatment and prevention of stroke, deep vein thrombosis and pulmonary embolism in atrial fibrillation patients.

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EASL Clinical Practice Guidelines for the management of patients with decompensated cirrhosis

The following Clinical Practice Guidelines (CPGs) represent the first CPGs on the management of decompensated cirrhosis.

Added 1 year ago

A practical guideline for the haematological management of major haemorrhage

The aim of these updated guidelines is to provide recommendations for the haematological management of major haemorrhage in any clinical situation...

Added 4 years ago

Acute upper gastrointestinal bleeding in over 16s: management

This guideline covers how upper gastrointestinal bleeding can be effectively managed in adults and young people aged 16 years and older.

Added 7 years ago

Search all guidelines for Gastrointestinal haemorrhage

Journal articles

Direct-Acting Oral Anticoagulants and Their Reversal Agents-An Update.

Background: Over the last ten years, a new class of drugs, known as the direct-acting oral anticoagulants (DOACs), have emerged at the forefront of anticoagulation therapy. Like the older generation anticoagulants, DOACs require...

Added 2 months ago

Andexanet alfa for reversal of factor Xa inhibitors: a critical review of the evidence.

Direct oral anticoagulants are associated with lower rates of bleeding than vitamin K antagonists, but life-threatening bleeding still occurs. Andexanet alfa is a catalytically inactive recombinant modified human factor Xa molecule that...

Added 2 months ago

Current Evidence for Pharmacologic Reversal Using Direct Oral Anticoagulants: What's New?

Direct oral anticoagulants are increasingly used in clinical practice and have addressed many of the issues related to vitamin K antagonists. However, the lack of reversal in life-threatening situations raises concerns regarding patient...

Added 3 months ago

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Clinical trials

A Study in Patients With Acute Major Bleeding to Evaluate the Ability of Andexanet Alfa to Reverse the Anticoagulation Effect of Direct and Indirect Oral Anticoagulants (Extension Study)

The purpose of this study is to evaluate the hemostatic efficacy of andexanet alfa in patients receiving a factor Xa inhibitor who are experiencing an acute major bleed. The safety of andexanet will also be studied.

Added 10 months ago

A Study in Older Subject to Evaluate the Safety and Ability of Andexanet Alfa to Reverse the Anticoagulation Effect of Rivaroxaban

The purpose of this study is to evaluate the ability of Andexanet Alfa to reverse the anticoagulation effect of Rivaroxaban.

Added 6 years ago

A Study in Older Subjects to Evaluate the Safety and Ability of Andexanet Alfa to Reverse the Anticoagulation Effect of Apixaban

The purpose of this stuy is to evaluate the ability of Andexanet Alfa to reverse the anticoagulation effect of Apixaban.

Added 6 years ago

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Yuli Pramana

Working at Dr Moewardi Hospital, Solo, central of Java, Indonesia. Subdivison of Gastroenterolgy and hepatology, Internal Medicine division.

Choosing Between Endoscopic Sclerotherapy And Endoscopic Ligation For Esophageal Varices

Endoscopic Sclerotherapy (ES) and Endoscopic Ligation (EL) were accepted in the treatment of esophageal varices bleeding in patients with liver cirrhosis. EL seemed to be superior to ES. If EL was difficult then ES should be performed.


A case of bleeding oesophageal varices

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Union of European Medical Specialists (via European Accreditation Council for CME)
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