Latest news articles

Added 3 days ago Drug news

Six-year Ocrevus data showed that earlier initiation and continuation of treatment reduced disability progression in multiple sclerosis

Genentech,, announced longer-term data from the Phase III open-label extension studies of OPERA I, OPERA II and ORATORIO showed that...

Added 3 days ago Drug news

Phase III trials of E 2609 for Alzheimers will be discontinued

Eisai Co and Biogen announced the decision to discontinue the Phase III clinical studies (MISSION AD1, AD2) on the investigational...

Added 4 days ago Drug news

FDA approves Ibsrela to treat irritable bowel syndrome with constipation

Ardelyx, Inc.has announced that the FDA has approved Ibsrela (tenapanor), a 50 mg, twice daily oral pill for the treatment...

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Learning Zones

An epgonline.org Learning Zone (LZ) is an area of the site dedicated to providing detailed self-directed medical education about a disease, condition or procedure.

EPNS 2019 Congress Highlights

EPNS 2019 Congress Highlights

The epgonline.org team is creating daily reports from the 13th European Paediatric Neurology Society (EPNS) Congress, held in Athens, Greece from 17th to 21st September 2019, to bring you coverage of cutting-edge science and advances in clinical care across all fields of paediatric neurology. 

Migraine Knowledge Centre

Migraine Knowledge Centre

The Migraine Knowledge Centre features latest research on the prevalence and impact of migraine, the proposed neurological basis of the condition (and how this is being translated into new and exciting drug therapies), as well as current patient care strategies collated from headache organisations worldwide.

Hereditary ATTR amyloidosis

Hereditary ATTR amyloidosis

Explore the pathophysiology, epidemiology and multi-system symptoms associated with hereditary ATTR amyloidosis, as well as how to achieve an early and accurate diagnosis.

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Guidelines

2019 AHA/ACC/HRS Focused Update of the 2014 AHA/ACC/HRS Guideline for the Management of Patients With Atrial Fibrillation: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart R

The scope of this focused update of the 2014 AF Guideline includes revisions to the section on anticoagulation (because of the approval of new medications and thromboembolism protection devices), revisions to the section...

Added 1 month ago

Multiple sclerosis in adults: management

This guideline covers diagnosing and managing multiple sclerosis in people aged 18 and over. It aims to improve the quality of life for adults with multiple sclerosis by promoting symptom management...

Added 4 years ago

Neuropathic pain in adults: pharmacological management in non-specialist settings

This guideline covers managing neuropathic pain (nerve pain) with pharmacological treatments (drugs) in adults in non-specialist settings. It aims to improve quality of life for people with conditions such as neuralgia, shingles and diabetic...

Added 5 years ago

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Journal articles

Reversal of oral anticoagulation in patients with acute intracerebral hemorrhage.

In light of an aging population with increased cardiovascular comorbidity, the use of oral anticoagulation (OAC) is steadily expanding. A variety of pharmacological alternatives to vitamin K antagonists (VKA) have emerged...

Added 12 days ago

Andexanet alfa for the reversal of factor Xa inhibitors.

Introduction: Andexanet alfa is a recombinant modified factor Xa protein that has been developed to reverse factor Xa inhibitors. Since May 2018, the FDA has approved its utilization in patients treated with apixaban and...

Added 12 days ago

Safety and Efficacy of Antithrombotic Strategies in Patients With Atrial Fibrillation Undergoing Percutaneous Coronary Intervention: A Network Meta-analysis of Randomized Controlled Trials.

Objective: To study the safety and efficacy of different antithrombotic regimens using a network meta-analysis of randomized controlled trials in this population.

Added 26 days ago

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Clinical trials

A Study to Evaluate the Safety, Tolerability, and Efficacy of BIIB017 (Peginterferon Beta-1a) in Pediatric Participants for the Treatment of Relapsing-Remitting Multiple Sclerosis

This study will evaluate the safety, tolerability, and descriptive efficacy of BIIB017 in pediatric participants with relapsing-remitting multiple sclerosis (RRMS) and to assess the pharmacokinetics (PK) of BIIB017 in pediatric participants...

Added 3 months ago

Efficacy and Safety of Butylphthalide Soft Capsule for the Treatment of Vascular Dementia

Butylphthalide soft capsule has been confirmed to have beneficial effects for patients with vascular dementia (VaD) in clinical trial of phase II study. So the investigators hypothesize that Butylphthalide soft capsule may have same beneficial...

Added 3 months ago

GAIN Trial: Phase 2/3 Study of COR388 in Subjects With Alzheimer's Disease

This is a randomized, double-blind, placebo-controlled study that will assess the efficacy, safety, and tolerability of 2 dose levels of COR388 in subjects with a clinical diagnosis of mild to moderate AD dementia.

Added 4 months ago

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Blog Posts

Dr Cornelia Meisenberg

Progressive Supranuclear Palsy (PSP)

Posted 2 months ago

What is Progressive Supranuclear Palsy (PSP)? Review the causes, treatment and current trials for this uncommon, degenerative disorder.

Alex Keen

EPAD – Changing the way we think about Alzheimer’s prevention

Posted 1 year ago

We spoke to Professor Craig Ritchie of the University of Edinburgh, the poject co-coordinator for EPAD, a collaborative venture that is facilitating meaningful progress in preventative Alzheimer’s therapies. Find out more about the project, its methods, expectations and goals.

Heather Lander, PhD

Zika Virus: old lessons from a newly emerging pathogen

Posted 3 years ago

Virologist-turned-Science Writer, Dr. Heather Lander, discusses the emergence of Zika virus and what we know so far.

CME

Shoulder examination and diagnosis

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Tricyclic antidepressants and headaches: systematic review and meta-analysis

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Breaking bad news: a how to do it guide

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