Latest news articles

Added 1 day ago Drug news

Phase IV AUGUSTUS trial of Eliquis shows superiority in non-valvular atrial fibrillation

Bristol-Myers Squibb/Pfizer announced results from the Phase IV AUGUSTUS trial evaluating Eliquis (apixaban) versus vitamin K antagonists (VKAs) in patients...

Added 3 days ago Drug news

Innovation Pharma seeks guidance from EMA for Brilacidin oral rinse in a Phase III program of severe Oral Mucositis

Innovation Pharmaceuticals, informs shareholders that necessary documentation has been completed for the European Medicines Agency (EMA) March 15, 2019 submission...

Added 5 days ago Drug news

EU gives CE mark approval for Watchman FLX Left Atrial Appendage Closure for stroke prevention

Boston Scientific announced it has received CE Mark and initiated a limited market release of the next generation Watchman FLX...

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Learning Zones

An epgonline.org Learning Zone (LZ) is an area of the site dedicated to providing detailed self-directed medical education about a disease, condition or procedure.

Migraine Knowledge Centre

Migraine Knowledge Centre

The Migraine Knowledge Centre features latest research on the prevalence and impact of migraine, the proposed neurological basis of the condition (and how this is being translated into new and exciting drug therapies), as well as current patient care strategies collated from headache organisations worldwide.

Cushing's Syndrome

Cushing's Syndrome

Cushing’s syndrome shares symptoms such as hypertension, glucose intolerance and obesity with other common conditions – how can you confidently diagnose this rare disorder?

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Chronic Lymphocytic Leukaemia (CLL)

Chronic Lymphocytic Leukaemia (CLL)

Refine your knowledge of chronic lymphocytic leukaemia (CLL) with information on pathophysiology, diagnosis, treatment options and more

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Guidelines

Clinical Practice Guidelines for the Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU (Devlin et al., 2018)

To update and expand the 2013 Clinical Practice Guidelines for the Management of Pain, Agitation, and Delirium in Adult Patients in the ICU.

Added 1 month ago

2018 update of the EULAR recommendations for the management of Behçet’s syndrome

These updated, evidence-based recommendations are intended to help physicians caring for patients with BS.

Added 8 months ago

EULAR recommendations for the use of imaging in large vessel vasculitis in clinical practice

These are the first EULAR recommendations providing up-to-date guidance for the role of imaging in the diagnosis and monitoring of patients with (suspected) LVV.

Added 8 months ago

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Journal articles

Apomorphine subcutaneous infusion in patients with Parkinson's disease with persistent motor fluctuations (TOLEDO): a multicentre, double-blind, randomised, placebo-controlled trial.

We aimed to investigate the efficacy and safety of apomorphine infusion compared with placebo in patients with Parkinson's disease with persistent motor fluctuations despite optimised oral or transdermal treatment.

Added 6 months ago

Global Prospective Safety Analysis of Rivaroxaban.

This study sought to assess the real-world safety profile of rivaroxaban through a pooled analysis of patients with AF enrolled in the XANTUS (Xarelto for Prevention of Stroke in Patients With Atrial Fibrillation) program worldwide.

Added 6 months ago

Efficacy and safety of erenumab (AMG334) in chronic migraine patients with prior preventive treatment failure: A subgroup analysis of a randomized, double-blind, placebo-controlled study.

Background: Erenumab was effective and well tolerated in a pivotal clinical trial of chronic migraine. Here, we evaluated efficacy and safety of monthly erenumab (70 mg or 140 mg) versus placebo in the subgroup of patients...

Added 6 months ago

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Clinical trials

HEAL STUDY (Hepatic Encephalopathy and Albumin Study) (HEAL)

This 6 week trial will study changes in cognition, HRQOL and inflammation in patients with covert HE after prior overt HE using multiple IV albumin infusions vs. placebo.

Added 1 day ago

Efficacy and Safety of Nerve Root Axial Decompression Surgery in The Treatment of Tethered Cord Syndrome

The aim of this study is to compare the effectiveness and safety of clinical outcomes between capsule surgery and conservative treatment in patients with TCS. A study hypothesis is that outcomes will be improved after capsule surgery.

Added 1 year ago

A Study to Explore the Long-Term Safety of TEV-48125 (Fremanezumab) for the Prevention of Cluster Headache (ENFORCE)

This is a 68-week study to evaluate the long-term safety of fremanezumab in patients with CH. Patients who complete the pivotal studies and enroll into the current study will visit the investigational center for IMP administration...

Added 8 months ago

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Blog Posts

Alex Keen

EPAD – Changing the way we think about Alzheimer’s prevention

Posted 7 months ago

We spoke to Professor Craig Ritchie of the University of Edinburgh, the poject co-coordinator for EPAD, a collaborative venture that is facilitating meaningful progress in preventative Alzheimer’s therapies. Find out more about the project, its methods, expectations and goals.

Heather Lander, PhD

Zika Virus: old lessons from a newly emerging pathogen

Posted 3 years ago

Virologist-turned-Science Writer, Dr. Heather Lander, discusses the emergence of Zika virus and what we know so far.

Hugh Harvey

Metrics Madness

Posted 3 years ago

You shouldn't judge a book by its cover. That much is true, but it's also common sense not to judge a book by measuring the whiteness of its pages, or the amount of hamsters you can place on it. So why do we measure the fabulous NHS with nonsense metrics?

CME

Shoulder examination and diagnosis

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Tricyclic antidepressants and headaches: systematic review and meta-analysis

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Breaking bad news: a how to do it guide

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