Latest news articles

Added 8 days ago Drug news

FDA approves Ayvakit to treat unresectable or metastatic gastrointestinal stromal tumor.- Blueprint Medicines

Blueprint Medicines Corporation announced that the FDA has approved Ayvakit (avapritinib) for the treatment of adults with unresectable or metastatic...

Added 19 days ago Drug news

FDA approves Lynparza for the maintenance treatment of germline BRCA-mutated metastatic pancreatic adenocarcinoma AstraZeneca + Merck Inc.

AstraZeneca and MSD Inc. have announced that Lynparza (olaparib) has been approved in the US for the maintenance treatment of...

Added 30 days ago Drug news

FDA gives priority review to Braftovi Doublet in metastatic colorectal cancer.- Pfizer

Pfizer announced that the FDA has accepted and granted priority review to the Company’s supplemental New Drug Application (sNDA) for...

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Learning Zones

An epgonline.org Learning Zone (LZ) is an area of the site dedicated to providing detailed self-directed medical education about a disease, condition or procedure.

Inflammatory Bowel Disease Knowledge Centre

Inflammatory Bowel Disease Knowledge Centre

The Inflammatory Bowel Disease (IBD) Knowledge Centre contains key information relating to the epidemiology and pathophysiology of Crohn’s disease and ulcerative colitis, highlighting prevalence, impact and unmet needs and the underlying inflammatory processes that drive IBD, considering some of the key inflammatory pathways.

Inflammatory bowel disease assessment tools

Inflammatory bowel disease assessment tools

'New IBD assessment tools at a glance' - an educational symposium sponsored by Sandoz.

Hereditary ATTR amyloidosis

Hereditary ATTR amyloidosis

Explore the pathophysiology, epidemiology and multi-system symptoms associated with hereditary ATTR amyloidosis, as well as how to achieve an early and accurate diagnosis.

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Guidelines

Gastro-oesophageal reflux disease and dyspepsia in adults: investigation and management

This guideline update covers adults (18 years and older) with symptoms of dyspepsia, symptoms suggestive of GORD, or both. It...

Added 5 years ago

Gastro-oesophageal reflux disease in children and young people: diagnosis and management

This guideline covers diagnosing and managing gastro-oesophageal reflux disease in children and young people (under 18s).

Added 5 years ago

Ulcerative colitis: management

This guideline covers the management of ulcerative colitis in children, young people and adults. It aims to help professionals to provide consistent high-quality care and it highlights the importance of advice and support...

Added 5 months ago

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Journal articles

Biosimilars in rheumatology: A review of the evidence and their place in the treatment algorithm.

Determining biosimilarity involves a comprehensive exercise with a focus on determining the comparability of the molecular characteristics and preclinical profile of the biosimilar and reference product, such that there is less need for...

Added 2 days ago

Comorbidities in inflammatory bowel disease: a call for action.

Inflammatory bowel disease (IBD) is a chronic systemic inflammatory condition. Previously, the focus has been on extraintestinal manifestations of IBD, including arthritis, psoriasis, and uveitis.

Added 2 days ago

The Economic Impact of the Introduction of Biosimilars in Inflammatory Bowel Disease.

Objective: Inflammatory bowel disease [IBD] entails a high economic burden to society. We aimed to estimate the current and future impact of the introduction of biosimilars for infliximab on IBD-related health care costs.

Added 2 days ago

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Clinical trials

Evaluate the Efficacy and Safety of HLX10 in Chronic Hepatitis B Patients

A multiple-center, open-label, Phase II clinical trial to evaluate the safety and the efficacy of HLX10 in chronic hepatitis B patients.

Added 2 months ago

Evaluating the Safety and Efficacy of Inarigivir in Non-cirrhotic Treatment Naive Subjects Infected With Hepatitis B Virus

An open-label, Phase 2, exploratory study to examine the safety and efficacy of inarigivir in non-cirrhotic, hepatitis B treatment-naive subjects with chronic HBV infection.

Added 2 months ago

A Phase 3/4 Clinical Study to Evaluate the Efficacy and Safety of Aramchol Versus Placebo in Subjects With NASH (ARMOR) (ARMOR)

The primary objectives of the study are to evaluate the effect of Aramchol as compared to placebo on NASH resolution, fibrosis improvement and clinical outcomes related to progression of liver disease.

Added 2 months ago

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Blog Posts

Allen Wellings

UEGW 2018 | Day 5 Highlights

Posted 1 year ago

A number of presentations and abstracts shared updates on the latest developments for new treatments and therapies, some of which are pioneering new modes of action. Here we look to the horizon, gaining insights into the latest data for novel treatments targeting Janus kinase (JAK) signalling, MAdCAM-1-mediated adhesion and the interleukin IL-23.
 

 

Georgina Mason

UEGW 2018 | Day 4 Highlights

Posted 1 year ago

While clinical trials have demonstrated the efficacy of new biologics used in ulcerative colitis and/or Crohn’s disease, it is apparent that patients enrolled into clinical trials are not representative of the general patient population. Real-world evidence offers the chance to fill this gap and provide insights into how these treatments perform in everyday clinical practice. In today’s article we review some of the real-world data shared at UEG Week on vedolizumab and ustekinumab, as well as comparison of the originator and biosimilar versions of infliximab.

Georgina Mason

UEGW 2018 | Day 3 Highlights

Posted 1 year ago

The introduction of biologic therapies in the last 20 years has revolutionised the management of IBD. However, questions remain over the best approach to its management, such as when to introduce, switch and de-escalate biologics. Several posters and presentations addressed these topics at UEG Week 2018; here is a selection of some of the highlights.

CME

Association of adherence to lifestyle recommendations and risk of colorectal cancer: a prospective Danish cohort study

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Union of European Medical Specialists (via European Accreditation Council for CME)
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A case of bleeding oesophageal varices

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Union of European Medical Specialists (via European Accreditation Council for CME)
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90

Idiopathic constipation and nocturnal enuresis in childhood: a guide to management: putting NICE guidelines into practice

Accrediting body
BMJ Learning - British Medical Learning
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90
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