Latest news articles

Added 22 hours ago Drug news

Updated data on PLEDGE program of relamorelin to treat diabetic gastroparesis.- Allergan

Allergan plc announced the expansion of the PLEDGE program with a fifth study now evaluating relamorelin, an investigational, ghrelin agonist...

Added 4 days ago Drug news

FDA approves Cyramza for patients with hepatocellular carcinoma with an alpha-fetoprotein .- Eli Lilly

Eli Lilly and Company announced that the FDA has approved Cyrazma (ramucirumab injection, 10 mg/mL solution), as a single agent,...

Added 7 days ago Drug news

Study of Signatera ctDNA assay in colorectal cancer published in JAMA Oncology.- Natera

A new clinical study shows that Natera's Signatera ctDNA assay identified colorectal cancer recurrence up to 16.5 months earlier than...

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Learning Zones

An epgonline.org Learning Zone (LZ) is an area of the site dedicated to providing detailed self-directed medical education about a disease, condition or procedure.

Inflammatory Bowel Disease Knowledge Centre

Inflammatory Bowel Disease Knowledge Centre

The Inflammatory Bowel Disease (IBD) Knowledge Centre contains key information relating to the epidemiology and pathophysiology of Crohn’s disease and ulcerative colitis, highlighting prevalence, impact and unmet needs and the underlying inflammatory processes that drive IBD, considering some of the key inflammatory pathways.

Inflammatory bowel disease assessment tools

Inflammatory bowel disease assessment tools

'New IBD assessment tools at a glance' - an educational symposium sponsored by Sandoz.

Chronic Lymphocytic Leukaemia (CLL)

Chronic Lymphocytic Leukaemia (CLL)

Refine your knowledge of chronic lymphocytic leukaemia (CLL) with information on pathophysiology, diagnosis, treatment options and more

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Guidelines

EASL Clinical Practice Guidelines on hepatitis E virus infection

Infection with hepatitis E virus (HEV) is a significant cause of morbidity and mortality, representing an important global health problem. Our understanding of HEV has changed completely over the past decade.

Added 11 months ago

UK guidelines on oesophageal dilatation in clinical practice

These guidelines deal specifically with the dilatation procedure using balloon or bougie devices as a primary treatment strategy for non-malignant narrowing of the oesophagus.

Added 11 months ago

2018 update of the EULAR recommendations for the management of Behçet’s syndrome

These updated, evidence-based recommendations are intended to help physicians caring for patients with BS.

Added 10 months ago

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Journal articles

Do we still need cryoprecipitate? Cryoprecipitate and fibrinogen concentrate as treatments for major hemorrhage - how do they compare?

This paper examines the current practice and evidence regarding the role of different modes of fibrinogen replacement in major hemorrhage in 3 distinct clinical settings: trauma, obstetric hemorrhage, and gastrointestinal...

Added 5 days ago

Faecal microbiota transplantation: a regulatory hurdle?

During faecal microbiota transplantation, stool from a healthy donor is transplanted to treat a variety of dysbiosis-associated gut diseases. Competent authorities are faced with the challenge to provide adequate regulation.

Added 15 days ago

Metabolic Biosynthesis Pathways Identified from Fecal Microbiome Associated with Prostate Cancer.

Objective: To investigate gut bacterial diversity, identify specific metabolic pathways associated with disease, and develop a microbiome risk profile for prostate cancer.

Added 15 days ago

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Clinical trials

Effects of Long-Term Administration of Human Albumin in Subjects With Decompensated Cirrhosis and Ascites (PRECIOSA)

This is a phase 3, multicenter, randomized, controlled, parallel-group, and open-label clinical study to evaluate the efficacy of standard medical treatment (SMT) + Albutein 20% administration versus SMT alone in subjects with...

Added 2 months ago

HEAL STUDY (Hepatic Encephalopathy and Albumin Study) (HEAL)

This 6 week trial will study changes in cognition, HRQOL and inflammation in patients with covert HE after prior overt HE using multiple IV albumin infusions vs. placebo.

Added 2 months ago

A Study of Atezolizumab in Combination With Bevacizumab Compared With Sorafenib in Patients With Untreated Locally Advanced or Metastatic Hepatocellular Carcinoma [IMbrave150]

This study will evaluate the efficacy and safety of atezolizumab in combination with bevacizumab compared with sorafenib in participants with locally advanced or metastatic Hepatocellular Carcinoma (HCC)...

Added 9 months ago

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Blog Posts

Allen Wellings

UEGW 2018 | Day 5 Highlights

Posted 6 months ago

A number of presentations and abstracts shared updates on the latest developments for new treatments and therapies, some of which are pioneering new modes of action. Here we look to the horizon, gaining insights into the latest data for novel treatments targeting Janus kinase (JAK) signalling, MAdCAM-1-mediated adhesion and the interleukin IL-23.
 

 

Stephen Smith

UEGW 2018 | Day 4 Highlights

Posted 6 months ago

While clinical trials have demonstrated the efficacy of new biologics used in ulcerative colitis and/or Crohn’s disease, it is apparent that patients enrolled into clinical trials are not representative of the general patient population. Real-world evidence offers the chance to fill this gap and provide insights into how these treatments perform in everyday clinical practice. In today’s article we review some of the real-world data shared at UEG Week on vedolizumab and ustekinumab, as well as comparison of the originator and biosimilar versions of infliximab.

Stephen Smith

UEGW 2018 | Day 3 Highlights

Posted 6 months ago

The introduction of biologic therapies in the last 20 years has revolutionised the management of IBD. However, questions remain over the best approach to its management, such as when to introduce, switch and de-escalate biologics. Several posters and presentations addressed these topics at UEG Week 2018; here is a selection of some of the highlights.

CME

Association of adherence to lifestyle recommendations and risk of colorectal cancer: a prospective Danish cohort study

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Union of European Medical Specialists (via European Accreditation Council for CME)
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A case of bleeding oesophageal varices

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Union of European Medical Specialists (via European Accreditation Council for CME)
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Idiopathic constipation and nocturnal enuresis in childhood: a guide to management: putting NICE guidelines into practice

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BMJ Learning - British Medical Learning
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