Data from clinicaltrials.gov - Curated by EPG Health - Last updated 22 October 2018

Although inotropes have a favorable effect on central hemodynamics in patients with heart failure, their effect on renal hemodynamics is incompletely defined.

purpose

Although inotropes have a favorable effect on central hemodynamics in patients with heart failure, their effect on renal hemodynamics is incompletely defined. The purpose of this study is to evaluate the efficacy of a 75 min intravenous infusion of levosimendan compared to a 75 min infusion of dobutamine on renal hemodynamics and function in patients with chronic heart failure and signs of cardiorenal syndrome. The investigators hypothesis is that patients treated with levosimendan will show greater increases in renal blood flow and glomerular filtration rate (GFR) than those treated with dobutamine.


Study Type: Interventional  (Clinical Trial)
Estimated Enrollment: 30 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary Purpose: Treatment
Official Title: Efficacy of Intravenous Levosimendan Compared With Dobutamine on Renal Hemodynamics and Function in Chronic Heart Failure
Study Start Date: April 2014
Estimated Primary Completion Date: December 2017
Estimated Study Completion Date: December 2017

Arm:
- Active Comparator:
Levosimendan
- Active Comparator: Dobutamine

Category Value
Date last updated at source 02-Feb-17
Study type(s) Interventional
Expected enrolment 30
Study start date 01-Apr-14
Estimated primary completion date 01-Dec-17

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