Latest news articles

Added 2 days ago Drug news

Update on phase III study P301 of SPN 810 explains variability of Impulsive aggression control in ADHD.- Supernus Pharma

Supernus Pharmaceuticals has provided an update on the results from the first Phase III study (P301) of SPN-810, a novel...

Added 2 days ago Drug news

EU approves extension of approval of Kalydeco to infants with CFTR cystic fibrosis.- Vertex Pharma

Vertex Pharmaceuticals announced that the European Commission has granted approval of the label extension for Kalydeco (ivacaftor) to include the...

Added 9 days ago Drug news

Phase III study of Brabafen in Dravet Syndrome published in JAMA Neurology.- Zogenix

Using Brabafen (fenfluramine) from Zogenix in an antiseizure medication regimen that includes the anticonvulsant stiripentol significantly reduces seizures in Dravet...

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Learning Zones

An epgonline.org Learning Zone (LZ) is an area of the site dedicated to providing detailed self-directed medical education about a disease, condition or procedure.

EPNS 2019 Congress Highlights

EPNS 2019 Congress Highlights

The epgonline.org team is creating daily reports from the 13th European Paediatric Neurology Society (EPNS) Congress, held in Athens, Greece from 17th to 21st September 2019, to bring you coverage of cutting-edge science and advances in clinical care across all fields of paediatric neurology. 

Nephropathic Cystinosis

Nephropathic Cystinosis

Learn about the use of cystine-depleting pharmacotherapy and other supportive care measures for patients with nephropathic cystinosis.

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Chronic Lymphocytic Leukaemia (CLL)

Chronic Lymphocytic Leukaemia (CLL)

Refine your knowledge of chronic lymphocytic leukaemia (CLL) with information on pathophysiology, diagnosis, treatment options and more

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Guidelines

Cannabis-based medicinal products

This guideline covers prescribing of cannabis-based medicinal products for people with intractable nausea and vomiting, chronic pain, spasticity and severe treatment-resistant epilepsy.

Added 8 days ago

Fever in under 5s: assessment and initial management

This guideline covers the assessment and early management of fever with no obvious cause in children aged under 5. It aims to improve clinical assessment and help healthcare professionals diagnose serious illness among young children...

Added 6 years ago

Epilepsies: diagnosis and management

The guideline covers diagnosing, treating and managing epilepsy and seizures in children, young people and adults in primary and secondary care.

Added 7 years ago

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Journal articles

Efficacy and tolerability of a pasteurised human fibrinogen concentrate in patients with congenital fibrinogen deficiency.

The efficacy and tolerability of a pasteurised human fibrinogen concentrate were assessed in an open, multi-centre, non-controlled retrospective study in patients with congenital fibrinogen deficiency.

Added 45 minutes ago

Hemostatic effects of fibrinogen concentrate compared with cryoprecipitate in children after cardiac surgery: a randomized pilot trial.

Objectives: Acute acquired hypofibrinogenemia in children undergoing cardiac surgery is a major concern because it often results in perioperative bleeding and high rates of allogeneic blood transfusion.

Added 23 hours ago

Fibrinogen replacement therapy for congenital fibrinogen deficiency.

This review of published studies was conducted to derive data on patients with congenital fibrinogen deficiency (CFD), including dosing of fibrinogen replacement therapy, outcome, and adverse events, either temporally related...

Added 3 days ago

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Clinical trials

Study of Nusinersen (BIIB058) in Participants With Spinal Muscular Atrophy

The primary objective of the study is to examine the clinical efficacy of nusinersen administered intrathecally at higher doses to participants with spinal muscular atrophy (SMA).

Added 2 months ago

A Study of Ocrelizumab in Children and Adolescents With Relapsing-Remitting Multiple Sclerosis

This 2-year study will evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamic (PD) effects of ocrelizumab in children and adolescents ages >/= 10 to < 18 years with relapsing-remitting multiple sclerosis (RRMS).

Added 2 months ago

A Dose-finding Study of Inhaled OligoG vs Placebo in Patients With Cystic Fibrosis (SMR3372)

Randomized, double blind, placebo controlled study. The study has two parts:
Dose-finding part, followed by longer term follow-up (6 months)

Added 1 month ago

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Blog Posts

Heather Lander, PhD

Zika Virus: old lessons from a newly emerging pathogen

Posted 3 years ago

Virologist-turned-Science Writer, Dr. Heather Lander, discusses the emergence of Zika virus and what we know so far.

Am Ang Zhang

Autism: Challenges and Obstacles!

Posted 3 years ago

Retired child psychiatrist Am Ang Zhang discusses his experiences of working with the families of autistic children.

Am Ang Zhang

Autism: Frances Tustin and Entrenchment!

Posted 3 years ago

Am Ang Zhang discusses his work with pioneering child psychotherapist Frances Tustin, and his observations of entrenchment in autistic children.

CME

Management of nocturnal enuresis

Accrediting body
BMJ Learning - British Medical Learning
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1
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90

Idiopathic constipation and nocturnal enuresis in childhood: a guide to management: putting NICE guidelines into practice

Accrediting body
BMJ Learning - British Medical Learning
Credits available
1
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1
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90

Eczema in children: management and advice for parents

Accrediting body
MIMS Learning - Monthly Index of Medical Specialities
Credits available
0
Registration required
1
Subscription fee
15
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