Added 2 days ago Drug news

Update on phase III study P301 of SPN 810 explains variability of Impulsive aggression control in ADHD.- Supernus Pharma

Supernus Pharmaceuticals has provided an update on the results from the first Phase III study (P301) of SPN-810, a novel...

Added 2 days ago Drug news

EU approves extension of approval of Kalydeco to infants with CFTR cystic fibrosis.- Vertex Pharma

Vertex Pharmaceuticals announced that the European Commission has granted approval of the label extension for Kalydeco (ivacaftor) to include the...

Added 9 days ago Drug news

Phase III study of Brabafen in Dravet Syndrome published in JAMA Neurology.- Zogenix

Using Brabafen (fenfluramine) from Zogenix in an antiseizure medication regimen that includes the anticonvulsant stiripentol significantly reduces seizures in Dravet...

Cannabis-based medicinal products

This guideline covers prescribing of cannabis-based medicinal products for people with intractable nausea and vomiting, chronic pain, spasticity and severe treatment-resistant epilepsy.

Added 8 days ago

Fever in under 5s: assessment and initial management

This guideline covers the assessment and early management of fever with no obvious cause in children aged under 5. It aims to improve clinical assessment and help healthcare professionals diagnose serious illness among young children...

Added 6 years ago

Epilepsies: diagnosis and management

The guideline covers diagnosing, treating and managing epilepsy and seizures in children, young people and adults in primary and secondary care.

Added 7 years ago

Efficacy and tolerability of a pasteurised human fibrinogen concentrate in patients with congenital fibrinogen deficiency.

The efficacy and tolerability of a pasteurised human fibrinogen concentrate were assessed in an open, multi-centre, non-controlled retrospective study in patients with congenital fibrinogen deficiency.

Added 45 minutes ago

Hemostatic effects of fibrinogen concentrate compared with cryoprecipitate in children after cardiac surgery: a randomized pilot trial.

Objectives: Acute acquired hypofibrinogenemia in children undergoing cardiac surgery is a major concern because it often results in perioperative bleeding and high rates of allogeneic blood transfusion.

Added 23 hours ago

Fibrinogen replacement therapy for congenital fibrinogen deficiency.

This review of published studies was conducted to derive data on patients with congenital fibrinogen deficiency (CFD), including dosing of fibrinogen replacement therapy, outcome, and adverse events, either temporally related...

Added 3 days ago

Study of Nusinersen (BIIB058) in Participants With Spinal Muscular Atrophy

The primary objective of the study is to examine the clinical efficacy of nusinersen administered intrathecally at higher doses to participants with spinal muscular atrophy (SMA).

Added 2 months ago

A Study of Ocrelizumab in Children and Adolescents With Relapsing-Remitting Multiple Sclerosis

This 2-year study will evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamic (PD) effects of ocrelizumab in children and adolescents ages >/= 10 to < 18 years with relapsing-remitting multiple sclerosis (RRMS).

Added 2 months ago

A Dose-finding Study of Inhaled OligoG vs Placebo in Patients With Cystic Fibrosis (SMR3372)

Randomized, double blind, placebo controlled study. The study has two parts:
Dose-finding part, followed by longer term follow-up (6 months)

Added 1 month ago