Data from multiple sources - Curated by Toby Galbraith - Last updated 06 June 2017

Latest news articles

Added 2 days ago Drug news

Impact Biomedicines to develop fedratinib to treat myelofibrosis and polycythemia vera.

Impact Biomedicines announced its launch to pioneer the development of life-changing treatments for patients with myeloproliferative neoplasms and other cancers. The...

Added 5 days ago Drug news

Successful Phase III T3MPO-2 trial for tenapanor for irritable bowel syndrome with constipation (IBS-C).- Ardelyx.

Ardelyx, Inc. reported positive results from T3MPO-2, its second Phase III study of tenapanor for irritable bowel syndrome with constipation...

Added 6 days ago Drug news

FDA provides complete response letter for Dsuvia (sufentanil sublingual tablet) in acute pain.- AcelRx Pharmaceuticals.

AcelRx Pharmaceuticals has received a Complete Response Letter (CRL) from the FDA regarding its New Drug Application (NDA) for Dsuvia...

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Learning Zones

An epgonline.org Learning Zone (LZ) is an area of the site dedicated to providing detailed self-directed medical education about a disease, condition or procedure.

Breakthrough Cancer Pain Learning Zone

Invitation to watch the online broadcast of the BeCOn OWN event 'Shifting paradigms in BTcP management' on June 16 2017.

Visit Breakthrough Cancer Pain Learning Zone

Cushing's Syndrome

Cushing’s syndrome shares symptoms such as hypertension, glucose intolerance and obesity with other common conditions – how can you confidently diagnose this rare disorder?

Visit Cushing's Syndrome

Hyperammonaemia

Hyperammonaemia can result in serious neurological damage or death. Could you recognise the signs and symptoms?

Visit Hyperammonaemia

 

Guidelines

EANO–ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up of patients with leptomeningeal metastasis from solid tumours

These EANO-ESMO joint recommendations for the diagnosis and treatment of leptomeningeal metastasis from solid cancers represent the first European guideline initiative on this topic.

Added 7 days ago

Guidelines on Chronic Pelvic Pain

This guideline plays an important role in the process of consolidation and improvement of care for patients with abdominal and...

Added 1 year ago

Guidelines on Neuro-Urology

The European Association of Urology (EAU) Neuro-Urology Guidelines aim to provide information for clinical practitioners on the incidence, definitions, diagnosis,...

Added 1 year ago

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Journal articles

Long-term cognitive functioning in individuals with tyrosinemia type 1 treated with nitisinone and protein-restricted diet.

Introduction: Tyrosinemia Type 1 (HT1) is an autosomal recessive disorder caused by a defect in the enzyme fumarylacetoacetate hydroxylase in the tyrosine pathway. Implementation of nitisinone (NTBC) treatment...

Added 8 days ago

Evaluation of pre-symptomatic nitisinone treatment on long-term outcomes in Tyrosinemia type 1 patients: a systematic review.

Background: Tyrosinemia type 1 (TYR1) is a rare autosomal recessive disorder of amino acid metabolism that is fatal without treatment. With medication (nitisinone) and dietary restrictions outcomes are improved.

Added 8 days ago

Anticoagulation-associated intracranial haemorrhage in the era of reversal agents

In patients taking oral anticoagulants (OACs), the annual rate of intracranial hemorrhage is 0.3% to 0.6%. Of these bleeds, 46% to 86% are intracerebral; 13% to 45% are subdural, and 1% to 8% are subarachnoidal. 

Added 15 days ago

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Clinical trials

Sodium Oxybate for Treatment of Excessive Daytime Sleepiness and Cataplexy in Narcolepsy

The purpose of this study is to determine whether aFT218 is safe and effective for the treatment of excessive daytime...

Added 2 years ago

Three Doses of Lasmiditan (50 mg, 100 mg and 200 mg) Compared to Placebo in the Acute Treatment of Migraine (SPARTAN)

This is a prospective randomized, double-blind, placebo-controlled study in subjects with disabling migraine (Migraine Disability Assessment (MIDAS) score ≥ 11).

Added 27 days ago

Pembrolizumab Plus Bevacizumab for Treatment of Brain Metastases in Metastatic Melanoma or Non-small Cell Lung Cancer

The purpose of this phase 2 trial is to study the activity of pembrolizumab in combination with bevacizumab in patients...

Added 2 years ago

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Blog Posts

Heather Lander, PhD

Zika Virus: old lessons from a newly emerging pathogen

Posted 1 year ago

Virologist-turned-Science Writer, Dr. Heather Lander, discusses the emergence of Zika virus and what we know so far.

Hugh Harvey

Metrics Madness

Posted 2 years ago

You shouldn't judge a book by its cover. That much is true, but it's also common sense not to judge a book by measuring the whiteness of its pages, or the amount of hamsters you can place on it. So why do we measure the fabulous NHS with nonsense metrics?

Bob Bury

Community Mental Health Provision then and now - is all progress positive?

Posted 3 years ago

Bob Bury muses on the state of modern mental healthcare. Instead of asylums, patients are now part of the community. But what of those who fall through the cracks? How can GPs help patients who need emergency mental health care? Can we learn anything from the methods of the past? Are three letter acronyms helpful? Examining the politics and hurdles of the UK's modern Community Mental Health provision, Bob Bury questions what UK healthcare professionals can do better and how things should change.

CME

Chest x ray: an essential guide to interpretation

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Tricyclic antidepressants and headaches: systematic review and meta-analysis

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Breaking bad news: a how to do it guide

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