Data from multiple sources - Curated by Toby Galbraith - Last updated 27 February 2017

Latest news articles

Added 1 day ago Drug news

EU CHMP recommends approval of Besponsa (inotuzumab ozogamicin) for treating acute lymphoblastic leukaemia- Pfizer

The Committee for Medicinal Products for Human Use (CHMP) adopted a positive opinion, recommending the granting of a marketing authorisation...

Added 2 days ago Drug news

Amgen files sBLA with FDA and application for variation of MAA with EMA for Xgeva (denosumab) to prevent skeletal-related events (SREs) in solid tumors to include patients with multiple myeloma.-Amgen

Amgen has announced the submission of a supplemental Biologics License Application (sBLA) to the FDA and an application for a...

Added 3 days ago Drug news

NIH study of Promacta / Revolade (eltrombopag)positive for treatment of severe aplastic anemia.- Novartis

Novartis announced the publication of a study conducted by the National Heart, Lung, and Blood Institute (NHLBI) of the National...

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Learning Zones

An epgonline.org Learning Zone (LZ) is an area of the site dedicated to providing detailed self-directed medical education about a disease, condition or procedure.

Chronic Lymphocytic Leukaemia (CLL)

Refine your knowledge of chronic lymphocytic leukaemia (CLL) with information on pathophysiology, diagnosis, treatment options and more

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Oral Anticoagulation Reversal

Experts discuss the use of non-vitamin K oral anticoagulants in the treatment and prevention of stroke, deep vein thrombosis and pulmonary embolism in atrial fibrillation patients

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Transplantation

See information on best practice in solid organ transplantation, and expert discussions on related hot topics.

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Guidelines

ESMO Consensus Conference on Malignant Lymphoma: General Perspectives and Recommendations for Prognostic Tools in Mature B-cell Lymphomas and Chronic Lymphocytic Leukaemia

In order to complement the already available European Society for Medical Oncology (ESMO) Clinical Practice Guidelines for the diagnosis, treatment and follow-up of patients with malignant lymphomas, ESMO organised a consensus conference...

Added October 2016 ago

NCCN Clinical Practice Guidelines in Oncology: Chronic Lymphocytic Leukemia/Small Lymphocytic Leukemia

CLL remains the most prevalent adult lerkemia in Wester countries but is considered rare in regions such as East Asia. CLL/SLL comprises approximately 7% of newly diagnosed cases of NHL.

Added October 2016 ago

Newly Diagnosed and Relapsed Follicular Lymphoma: ESMO Clinical Practice Guidelines

Follicular lymphomas are the second most frequent subtype of nodal lymphoid malignancies in Western Europe. The annual incidence of this disease is rare but has increased during recent decades.

Added October 2016 ago

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Journal articles

Idelalisib for the treatment of chronic lymphocytic leukemia/small lymphocytic lymphoma.

Idelalisib is a first-in-class selective oral PI3Kδ inhibitor for the treatment of patients with relapsed chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma, a predominantly elderly population with high comorbidity.

Added April 2017 ago

Outcomes of patients with chronic lymphocytic leukemia treated with first-line idelalisib plus rituximab after cessation of treatment for toxicity.

Background: More active therapies are needed for older and unfit patients with chronic lymphocytic leukemia (CLL) who are not eligible for chemoimmunotherapy with fludarabine, cyclophosphamide, and rituximab.

Added April 2017 ago

Idelalisib in the management of lymphoma.

Inhibition of the phosphatidylinositol-3-kinase (PI3K) pathway as an anticancer therapeutic strategy was realized with the approval of the orally bioavailable small molecule PI3Kδ inhibitor idelalisib.

Added April 2017 ago

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Clinical trials

ASCT After a Rituximab/Ibrutinib/Ara-c Containing iNduction in Generalized Mantle Cell Lymphoma

The primary objective of the the trial is to establish one of three study arms...

Added July 2016 ago

Ibrutinib Before and After Stem Cell Transplant in Treating Patients With Relapsed or Refractory Diffuse Large B-cell Lymphoma

This randomized phase III trial studies ibrutinib to see how well it works compared to placebo when given before and after stem cell transplant

Added July 2016 ago

Ticagrelor And PrEconditioning in Patients With coronaRy Artery diSease (TAPER-S)

The aim of this study is to assess the pleiotropic effects of ticagrelor that could represent possible mechanisms for its...

Added June 2016 ago

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Blog Posts

Hugh Harvey

Metrics Madness

Posted 1 year ago

You shouldn't judge a book by its cover. That much is true, but it's also common sense not to judge a book by measuring the whiteness of its pages, or the amount of hamsters you can place on it. So why do we measure the fabulous NHS with nonsense metrics?

CME

A case of bleeding oesophageal varices

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Breaking bad news: a how to do it guide

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Treatment Optimisation in Chronic Lymphocytic Leukaemia

Treatment Optimisation in Chronic Lymphocytic Leukaemia
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