413 Results

A knowledgebase resource for interleukin-17 family mediated signaling.

Interleukin-17 (IL-17) belongs to a relatively new family of cytokines that has garnered attention as the signature cytokine of Th17 cells. This cytokine family consists of 6 ligands, which bind to 5 receptor subtypes and induce...

Novel therapies for immune-mediated inflammatory diseases: What can we learn from their use in rheumatoid arthritis, spondyloarthritis, systemic lupus erythematosus, psoriasis, Crohn's disease and ulcerative colitis?

The past three decades have witnessed remarkable advances in our ability to target specific elements of the immune and inflammatory response, fuelled by advances in both biotechnology and disease knowledge.

Infliximab in inflammatory bowel disease.

Anti-tumor necrosis factor (TNF) therapy has revolutionized the medical treatment of the inflammatory bowel diseases (IBD), Crohn’s disease (CD), and ulcerative colitis. Twenty years ago, infliximab became the first anti-TNF...

Natalizumab for induction of remission in Crohn's disease.

Background: This systematic review update summarizes the current evidence on the use of natalizumab for induction of remission in Crohn's disease (CD).

General and abdominal obesity in relation to the prevalence of irritable bowel syndrome.

Background: Earlier studies on the obesity‚ÄźIBS association have mostly been reported from Western nations, and limited data are available in this regard from developing countries. This study was performed to examine...

Migraine associated with gastrointestinal disorders: A pathophysiological explanation.

Background: Migraine is a highly prevalent, disabling, and costly disorder worldwide. From a long time ago, headaches have been known to be associated with gastrointestinal (GI) disorders. Headaches originating from gastric...

Role of Calcitonin Gene-related Peptide in Gastric Motility Function: Animal and Human Studies

Diabetes is one of the leading causes of gastroparesis. Gastroparesis is a state of partial gastric paralysis where gastric emptying is delayed due to slower or faster gastric motility. Over the years, many other distinct causes of...

The pharmacological basis of opioids.

An opioid is a chemical that binds to opioid receptors, which are widely distributed in the central and peripheral nervous system and gastrointestinal tract. The different effects elicited by activation of these receptors are due to...

Migraine and gastroparesis from a gastroenterologist's perspective.

Gastroparesis is a chronic stomach disorder manifested by delayed emptying of solids and liquids without evidence of mechanical obstruction. Evidence from pharmacokinetic and gastric motor studies conducted over the past 40 years...

Gastric stasis in migraine: more than just a paroxysmal abnormality during a migraine attack.

Objective: The aim of this article is to evaluate gastric motility and emptying in the ictal and interictal period in migraine.

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