Latest news articles

Added 2 minutes ago Drug news

Lilly announces phase III SEQUOIA study of pegilodecakin + FOLFOX in patients with metastatic pancreatic cancer did not meet primary endpoint of overall survival.

Eli Lilly and Company announced top-line results from its Phase III SEQUOIA trial evaluating pegilodecakin plus FOLFOX (folinic acid, 5-FU,...

Added 5 days ago Drug news

Phase III MAP US study of RHB 104 meets endpoint in Crohn’s disease.-RedHill Biopharma

RedHill Biopharma announced full Week 52 results for all subjects in the previously announced positive Phase III randomized, controlled study...

Added 14 days ago Drug news

Deciphera Pharmaceuticals announces positive results from INVICTUS pivotal phase III study of ripretinib in patients with advanced gastrointestinal stromal tumors.-

Deciphera Pharmaceuticals, Inc. announced the late-breaking presentation of results from the INVICTUS pivotal Phase III clinical study of ripretinib in...

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Learning Zones

An epgonline.org Learning Zone (LZ) is an area of the site dedicated to providing detailed self-directed medical education about a disease, condition or procedure.

Inflammatory Bowel Disease Knowledge Centre

Inflammatory Bowel Disease Knowledge Centre

The Inflammatory Bowel Disease (IBD) Knowledge Centre contains key information relating to the epidemiology and pathophysiology of Crohn’s disease and ulcerative colitis, highlighting prevalence, impact and unmet needs and the underlying inflammatory processes that drive IBD, considering some of the key inflammatory pathways.

Inflammatory bowel disease assessment tools

Inflammatory bowel disease assessment tools

'New IBD assessment tools at a glance' - an educational symposium sponsored by Sandoz.

Fluid Management

Fluid Management

Are you up-to-date with the latest evidence of effective procedures for fluid management?

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Guidelines

Ulcerative colitis: management

This guideline covers the management of ulcerative colitis in children, young people and adults. It aims to help professionals to provide consistent high-quality care and it highlights the importance of advice and support...

Added 2 months ago

Crohn's disease: management

Crohn's disease is a chronic inflammatory disease that mainly affects the gastrointestinal tract. The disease may be progressive in some people, and a proportion may develop extra-intestinal manifestations.

Added 7 years ago

Pancreatitis

This guideline covers managing acute and chronic pancreatitis in children, young people and adults.

Added 2 months ago

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Journal articles

Gluten sensitivity and epilepsy: a systematic review.

Objective: The aim of this systematic review was to establish the prevalence of epilepsy in patients with coeliac disease (CD) or gluten sensitivity (GS) and vice versa and to characterise the phenomenology of the epileptic...

Added 10 days ago

Diagnosis and management of Duchenne muscular dystrophy, part 1: diagnosis, and neuromuscular, rehabilitation, endocrine, and gastrointestinal and nutritional management.

In part 1 of this three-part update, we present care considerations for diagnosis of DMD and neuromuscular, rehabilitation, endocrine (growth, puberty, and adrenal insufficiency), and gastrointestinal (including nutrition and...

Added 23 days ago

Diagnosis and management of spinal muscular atrophy: Part 1: Recommendations for diagnosis, rehabilitation, orthopedic and nutritional care.

In part 1 we present the methods used to achieve these recommendations, and an update on diagnosis, rehabilitation, orthopedic and spinal management; and nutritional, swallowing and gastrointestinal management.

Added 24 days ago

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Clinical trials

Safety, Tolerability, and Efficacy of Monotherapy and Combination Regimens in Adults With Nonalcoholic Steatohepatitis (NASH)

The primary objective of this study is to evaluate the safety and tolerability of study drug(s) in adults with nonalcoholic steatohepatitis (NASH).

Added 2 months ago

Saroglitazar Magnesium in the Treatment of Non-Alcoholic Steatohepatitis (EVIDENCES VI)

This is a randomized, double-blind, placebo-controlled study to evaluate safety and efficacy of Saroglitazar Magnesium 2 mg and 4 mg in patients with NASH.

Added 2 months ago

A Phase 2 Study of Elobixibat in Adults With NAFLD or NASH

Double-blind, randomized, placebo-controlled study to explore the efficacy and safety of elobixibat compared to placebo in adults with NAFLD (nonalcoholic fatty liver disease) or NASH...

Added 2 months ago

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Blog Posts

Allen Wellings

UEGW 2018 | Day 5 Highlights

Posted 11 months ago

A number of presentations and abstracts shared updates on the latest developments for new treatments and therapies, some of which are pioneering new modes of action. Here we look to the horizon, gaining insights into the latest data for novel treatments targeting Janus kinase (JAK) signalling, MAdCAM-1-mediated adhesion and the interleukin IL-23.
 

 

Georgina Mason

UEGW 2018 | Day 4 Highlights

Posted 11 months ago

While clinical trials have demonstrated the efficacy of new biologics used in ulcerative colitis and/or Crohn’s disease, it is apparent that patients enrolled into clinical trials are not representative of the general patient population. Real-world evidence offers the chance to fill this gap and provide insights into how these treatments perform in everyday clinical practice. In today’s article we review some of the real-world data shared at UEG Week on vedolizumab and ustekinumab, as well as comparison of the originator and biosimilar versions of infliximab.

Georgina Mason

UEGW 2018 | Day 3 Highlights

Posted 11 months ago

The introduction of biologic therapies in the last 20 years has revolutionised the management of IBD. However, questions remain over the best approach to its management, such as when to introduce, switch and de-escalate biologics. Several posters and presentations addressed these topics at UEG Week 2018; here is a selection of some of the highlights.

CME

Association of adherence to lifestyle recommendations and risk of colorectal cancer: a prospective Danish cohort study

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Union of European Medical Specialists (via European Accreditation Council for CME)
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A case of bleeding oesophageal varices

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Idiopathic constipation and nocturnal enuresis in childhood: a guide to management: putting NICE guidelines into practice

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BMJ Learning - British Medical Learning
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