Latest news articles

Added 16 hours ago Drug news

FDA approves Avsola, infliximab biosimilar, for all indications of the reference product.- Amgen

Amgen has announced that the FDA has approved Avsola (infliximab-axxq) for all approved indications of the reference product, Remicade (infliximab):...

Added 4 days ago Drug news

Mylan and Biocon launch Ogivri in the US, being the first biosimilar trastuzumab approved by the FDA.

Mylan N.V. and Biocon Ltd. announced the U.S. launch of Ogivri (trastuzumab-dkst), a biosimilar to Herceptin (trastuzumab). Ogivri is available...

Added 14 days ago Drug news

Tecentriq in combination with Avastin improves overall survival in people with the most common form of liver cancer. Genentech/Roche

Genentech, a member of the Roche Group presented positive results from the Phase III IMbrave150 study evaluating Tecentriq (atezolizumab) in...

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Learning Zones

An epgonline.org Learning Zone (LZ) is an area of the site dedicated to providing detailed self-directed medical education about a disease, condition or procedure.

Inflammatory Bowel Disease Knowledge Centre

Inflammatory Bowel Disease Knowledge Centre

The Inflammatory Bowel Disease (IBD) Knowledge Centre contains key information relating to the epidemiology and pathophysiology of Crohn’s disease and ulcerative colitis, highlighting prevalence, impact and unmet needs and the underlying inflammatory processes that drive IBD, considering some of the key inflammatory pathways.

Inflammatory bowel disease assessment tools

Inflammatory bowel disease assessment tools

'New IBD assessment tools at a glance' - an educational symposium sponsored by Sandoz.

Fluid Management

Fluid Management

Are you up-to-date with the latest evidence of effective procedures for fluid management?

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Guidelines

Gastro-oesophageal reflux disease and dyspepsia in adults: investigation and management

This guideline update covers adults (18 years and older) with symptoms of dyspepsia, symptoms suggestive of GORD, or both. It...

Added 5 years ago

Gastro-oesophageal reflux disease in children and young people: diagnosis and management

This guideline covers diagnosing and managing gastro-oesophageal reflux disease in children and young people (under 18s).

Added 4 years ago

Ulcerative colitis: management

This guideline covers the management of ulcerative colitis in children, young people and adults. It aims to help professionals to provide consistent high-quality care and it highlights the importance of advice and support...

Added 3 months ago

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Journal articles

Direct-Acting Oral Anticoagulants and Their Reversal Agents-An Update.

Background: Over the last ten years, a new class of drugs, known as the direct-acting oral anticoagulants (DOACs), have emerged at the forefront of anticoagulation therapy. Like the older generation anticoagulants, DOACs require...

Added 16 days ago

Andexanet alfa for reversal of factor Xa inhibitors: a critical review of the evidence.

Direct oral anticoagulants are associated with lower rates of bleeding than vitamin K antagonists, but life-threatening bleeding still occurs. Andexanet alfa is a catalytically inactive recombinant modified human factor Xa molecule that...

Added 16 days ago

Efficacy and Safety of Vedolizumab Subcutaneous Formulation in a Randomized Trial of Patients With Ulcerative Colitis.

Background & Aims: Maintenance treatment with vedolizumab, a monoclonal antibody that inhibits the gut-selective α4β7 integrin, is administered intravenously. Some patients might prefer a subcutaneous formulation of...

Added 19 days ago

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Clinical trials

Evaluate the Efficacy and Safety of HLX10 in Chronic Hepatitis B Patients

A multiple-center, open-label, Phase II clinical trial to evaluate the safety and the efficacy of HLX10 in chronic hepatitis B patients.

Added 1 month ago

Evaluating the Safety and Efficacy of Inarigivir in Non-cirrhotic Treatment Naive Subjects Infected With Hepatitis B Virus

An open-label, Phase 2, exploratory study to examine the safety and efficacy of inarigivir in non-cirrhotic, hepatitis B treatment-naive subjects with chronic HBV infection.

Added 1 month ago

A Phase 3/4 Clinical Study to Evaluate the Efficacy and Safety of Aramchol Versus Placebo in Subjects With NASH (ARMOR) (ARMOR)

The primary objectives of the study are to evaluate the effect of Aramchol as compared to placebo on NASH resolution, fibrosis improvement and clinical outcomes related to progression of liver disease.

Added 1 month ago

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Blog Posts

Allen Wellings

UEGW 2018 | Day 5 Highlights

Posted 1 year ago

A number of presentations and abstracts shared updates on the latest developments for new treatments and therapies, some of which are pioneering new modes of action. Here we look to the horizon, gaining insights into the latest data for novel treatments targeting Janus kinase (JAK) signalling, MAdCAM-1-mediated adhesion and the interleukin IL-23.
 

 

Georgina Mason

UEGW 2018 | Day 4 Highlights

Posted 1 year ago

While clinical trials have demonstrated the efficacy of new biologics used in ulcerative colitis and/or Crohn’s disease, it is apparent that patients enrolled into clinical trials are not representative of the general patient population. Real-world evidence offers the chance to fill this gap and provide insights into how these treatments perform in everyday clinical practice. In today’s article we review some of the real-world data shared at UEG Week on vedolizumab and ustekinumab, as well as comparison of the originator and biosimilar versions of infliximab.

Georgina Mason

UEGW 2018 | Day 3 Highlights

Posted 1 year ago

The introduction of biologic therapies in the last 20 years has revolutionised the management of IBD. However, questions remain over the best approach to its management, such as when to introduce, switch and de-escalate biologics. Several posters and presentations addressed these topics at UEG Week 2018; here is a selection of some of the highlights.

CME

Association of adherence to lifestyle recommendations and risk of colorectal cancer: a prospective Danish cohort study

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Union of European Medical Specialists (via European Accreditation Council for CME)
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A case of bleeding oesophageal varices

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Idiopathic constipation and nocturnal enuresis in childhood: a guide to management: putting NICE guidelines into practice

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BMJ Learning - British Medical Learning
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