Data from multiple sources - Curated by Toby Galbraith - Last updated 04 January 2017

Latest news articles

Added 14 days ago Drug news

FDA issues Complete Response Letter for CL 108 (hydrocodone, acetaminophen, promethazine), an investigational treatment for the management of pain.-Charleston Labs + Daiichi Sankyo.

Charleston Laboratories, Inc., and Daiichi Sankyo, Inc., confirmed that the FDA has issued a Complete Response Letter (CRL) regarding the...

Added 27 days ago Drug news

FDA accepts filing of sBLA for Actemra (tocilizumab) for the treatment of Giant Cell Arteritis and grants priority review.- Genetench/Roche

Genentech, announced that the FDA has accepted the company’s Supplemental Biologics License Application (sBLA) for Actemra (tocilizumab) for the treatment...

Added 1 month ago Drug news

Phase III (AB06006) study of masitinib in severe indolent systemic mastocytosis is published in The Lancet- AB Science SA

AB Science SA announced that results from the pivotal phase III (AB06006) study of masitinib in severe indolent systemic mastocytosis...

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Learning Zones

An Learning Zone (LZ) is an area of the site dedicated to providing detailed self-directed medical education about a disease, condition or procedure.


Hyperammonaemia can result in serious neurological damage or death. Could you recognise the signs and symptoms?

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Fluid Management

Are you up-to-date with the latest evidence of effective procedures for fluid management?

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Oral Anticoagulation Reversal

Experts discuss the use of non-vitamin K oral anticoagulants in the treatment and prevention of stroke, deep vein thrombosis and pulmonary embolism in atrial fibrillation patients

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2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure

The aim of this document is to provide practical, evidence-based guidelines for the diagnosis and treatment of HF. The principal...

Added 9 months ago

BTS/ICS Guidelines for the Ventilatory Management of Acute Hypercapnic Respiratory Failure in Adults

The aim of the guideline is to draw attention to the evidence of suboptimal care in AHRF in the UK,...

Added 10 months ago

Guidelines on Urological Trauma

The European Association of Urology (EAU) Guidelines Group for Urological Trauma prepared these guidelines in order to assist medical professionals...

Added 11 months ago

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Journal articles

Role of prothrombin complex concentrate (PCC) in acute intracerebral hemorrhage with positive CTA spot sign: An institutional experience at a regional and state designated stroke center.

Our objective is to identify the effect of prothrombin complex concentrate in acute intracranial hemorrhage by evaluating intraparenchymal hematoma expansion between initial and follow-up head CT at 5-24 h in those with positive CTA spot sign.

Added 19 days ago

Assessing the Efficacy of Prothrombin Complex Concentrate in Multiply Injured Patients With High-Energy Pelvic and Extremity Fractures

the use of PCC for reversing coagulopathy in multiply injured patients with pelvic and/or lower extremity fractures remains unclear. This study assesses the efficacy of PCC for reversing coagulopathy in this group of patients.

Added 1 month ago

Prothrombin complex concentrate versus fresh-frozen plasma for reversal of coagulopathy of trauma: is there a difference?

This retrospective matched-cohort study compared fresh frozen plasma (FFP) alone with combination FFP and prothrombin complex concentrate (PCC) for reversing trauma induced coagulopathy. 

Added 1 month ago

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