Data from multiple sources - Curated by Toby Galbraith - Last updated 27 February 2017

Latest news articles

Added 9 days ago Drug news

Post-market approval study evaluated the Subcutaneous Implantable Defibrillator (S-ICD) System and showed a high success rate and a low complication rate. -Boston Scientific

Boston Scientific announced results from the U.S. post-market approval study evaluating 'real-world' patients implanted with the Subcutaneous Implantable Defibrillator (S-ICD)...

Added 1 month ago Congress news

International Society on Thrombosis and Hemostasis (ISTH) announce upcoming Berlin congress

The International Society on Thrombosis and Haemostasis (ISTH) today announced its upcoming ISTH 2017 Congress is expected to surpass its own records.

 

Added 1 month ago Drug news

Phase III study of KRN 23 (burosumab) in X-linked hypophosphatemia meets primary endpoint- Ultragenyx Pharmaceutical/ Kyowa Hakko Kirin

Ultragenyx Pharmaceutical, Kyowa Hakko Kirin Co and Kyowa Kirin International announced positive 24-week data from the randomised, double-blind, placebo-controlled Phase...

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Learning Zones

An epgonline.org Learning Zone (LZ) is an area of the site dedicated to providing detailed self-directed medical education about a disease, condition or procedure.

Fluid Management

Are you up-to-date with the latest evidence of effective procedures for fluid management?

Visit Fluid Management

Hyperammonaemia

Hyperammonaemia can result in serious neurological damage or death. Could you recognise the signs and symptoms?

Visit Hyperammonaemia

 

Guidelines

Comfort and patient-centred care without excessive sedation: the eCASH concept.

We propose an integrated and adaptable approach to improve patient care and clinical outcomes through analgesia and light sedation, initiated early during an episode of critical illness and as a priority of care.

Added 2 months ago

BTS/ICS Guidelines for the Ventilatory Management of Acute Hypercapnic Respiratory Failure in Adults

The aim of the guideline is to draw attention to the evidence of suboptimal care in AHRF in the UK,...

Added 1 year ago

Care of dying adults in the last days of life

This guideline covers the clinical care of adults (18 years and over) who are dying during the last 2 to...

Added 1 year ago

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Journal articles

Early goal-directed therapy in the treatment of severe sepsis and septic shock.

Goal-directed therapy has been used for severe sepsis and septic shock in the intensive care unit.

Added 3 days ago

Early, goal-directed therapy for septic shock – a patient-level meta-analysis.

After a single-center trial and observational studies suggesting that early, goal-directed therapy (EGDT) reduced mortality from septicshock, three multicenter trials (ProCESS, ARISE, and ProMISe) showed no benefit.

Added 3 days ago

Perioperative intravenous fluid prescribing: a multi-centre audit.

Excessive or inadequate intravenous fluid given in the perioperative period can affect outcomes. A number of guidelines exist but these can conflict with the entrenched practice, evidence base and prescriber knowledge.

Added 1 month ago

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Clinical trials

Comparison of Propofol and Dexmedetomidine to Treat Hyperactive and Mixed ICU Delirium - the Basel ProDex Randomized Trial

In this randomized study, the investigators aim to test the hypothesis that the reinstitution of a normal circadian rhythm by continuous infusions of dexmedetomidine compared to propofol between 8pm and 6am...

Added 2 months ago

The Neuroprotective Effects of Dexmedetomidine During Brain Surgery

Dexmedetomidine (DEX) is a Alpha-2 specific agonist, is a common ICU sedation medication. In brain tumor resection craniotomy, it is proven to be effective in improving postoperative hypertension and...

Added 2 months ago

Bioavailability of Subcutaneously Given Dexmedetomidine in Healthy Volunteers

The aim of this study is to investigate the pharmacokinetics of subcutaneously administered dexmedetomidine in healthy volunteers. The absolute bioavailability of subcutaneously...

Added 2 months ago

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Blog Posts

Hugh Harvey

Metrics Madness

Posted 1 year ago

You shouldn't judge a book by its cover. That much is true, but it's also common sense not to judge a book by measuring the whiteness of its pages, or the amount of hamsters you can place on it. So why do we measure the fabulous NHS with nonsense metrics?

Peter English

The advance decision not to attempt cardiopulmonary resuscitation

Posted 2 years ago

Decisions to start cardiopulmonary resuscitation (CPR), or to decide in advance to issue a "do not attempt (cardiopulmonary) resuscitation" (DNAR) notice have always been a hot topic in clinical medicine. It may have become even more so since a recent (June 2014) court decision. This post discusses some of the issues and legalities around DNAR decisions.

CME

Chest x ray: an essential guide to interpretation

Accrediting body
Union of European Medical Specialists (via European Accreditation Council for CME)
Credits available
1
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1
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90

Breaking bad news: a how to do it guide

Accrediting body
Union of European Medical Specialists (via European Accreditation Council for CME)
Credits available
0
Registration required
1
Subscription fee
90

Fluid management in acutely ill patients

Accrediting body
BMJ Learning - British Medical Learning
Credits available
1
Registration required
1
Subscription fee
90
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