Data from multiple sources - Curated by Toby Galbraith - Last updated 04 January 2017

Latest news articles

Added 1 month ago Drug news

FDA refuses a filing application for Xaracoll (bupivacaine-collagen matrix) in pain treatment- Innocoll

Innocoll has received a Refusal to File letter from the United States Food and Drug Administration (FDA) for Xaracoll (bupivacaine-collagen...

Added 1 month ago Drug news

FDA provides complete response for application for CEM 101 (solithromycin) in community-acquired bacterial pneumonia- Cempra

Cempra has received a Complete Response Letter (CRL) from the FDA relating to the company’s new drug applications (NDAs) for...

Added 2 months ago Drug news

FDA indication expanded for Impella CP heart pump during percutaneous coronary interventions- Abiomed

Abiomed has expanded its FDA pre-market approval (PMA) for Impella heart pump use in high-risk percutaneous coronary interventions (PCI) to...

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Learning Zones

An Learning Zone (LZ) is an area of the site dedicated to providing detailed self-directed medical education about a disease, condition or procedure.

Fluid Management

Are you up-to-date with the latest evidence of effective procedures for fluid management?

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Hyperammonaemia can result in serious neurological damage or death. Could you recognise the signs and symptoms?

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Oral Anticoagulation Reversal

Experts discuss the use of non-vitamin K oral anticoagulants in the treatment and prevention of stroke, deep vein thrombosis and pulmonary embolism in atrial fibrillation patients

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BTS/ICS Guidelines for the Ventilatory Management of Acute Hypercapnic Respiratory Failure in Adults

The aim of the guideline is to draw attention to the evidence of suboptimal care in AHRF in the UK,...

Added 10 months ago

Care of dying adults in the last days of life

This guideline covers the clinical care of adults (18 years and over) who are dying during the last 2 to...

Added 1 year ago

Guidelines on the management and admission to intensive care of critically ill adult patients with haematological malignancy in the UK

This guideline is intended to be of use to haematologists and intensivists practising in the UK, and outlines some of...

Added 1 year ago

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Journal articles

Implementation of goal-directed fluid therapy during hip revision arthroplasty: a matched cohort study.

Several randomized controlled trials (RCTs) have demonstrated that intraoperative goal-directed fluid therapy (GDFT) can decrease postsurgical complications in patients undergoing major abdominal surgery.

Added 13 days ago

Role of prothrombin complex concentrate (PCC) in acute intracerebral hemorrhage with positive CTA spot sign: An institutional experience at a regional and state designated stroke center.

Our objective is to identify the effect of prothrombin complex concentrate in acute intracranial hemorrhage by evaluating intraparenchymal hematoma expansion between initial and follow-up head CT at 5-24 h in those with positive CTA spot sign.

Added 20 days ago

Assessing the Efficacy of Prothrombin Complex Concentrate in Multiply Injured Patients With High-Energy Pelvic and Extremity Fractures

the use of PCC for reversing coagulopathy in multiply injured patients with pelvic and/or lower extremity fractures remains unclear. This study assesses the efficacy of PCC for reversing coagulopathy in this group of patients.

Added 1 month ago

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Blog Posts

Peter English

The advance decision not to attempt cardiopulmonary resuscitation

Posted 2 years ago

Decisions to start cardiopulmonary resuscitation (CPR), or to decide in advance to issue a "do not attempt (cardiopulmonary) resuscitation" (DNAR) notice have always been a hot topic in clinical medicine. It may have become even more so since a recent (June 2014) court decision. This post discusses some of the issues and legalities around DNAR decisions.