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Drug news

FDA approves Bevyxxa (betrixaban) to treat venous thromboembolism (VTE).-Portola Pharmaceuticals Inc,

Portola Pharmaceuticals Inc. announced the FDA has approved Bevyxxa (betrixaban), the first and only anticoagulant for hospital and extended duration...

Drug news

Phase III CANTOS study of ACZ 885 (canakinumab) showed a reduction of CV risk in patients with prior heart attack and inflammatory atherosclerosis.- Novartis

Novartis has announced topline results from the global Phase III CANTOS study investigating the efficacy, safety and tolerability of ACZ...

Drug news

MHRA in the UK grants Raxone (idebenone) a positive scientific opinion to treat Duchenne Muscular Dystrophy under Early Access to Medicines Scheme.- Santhera Pharmaceuticals

Santhera Pharmaceuticals announces that the UK's Medicines and Healthcare products Regulatory Agency (MHRA) has granted Raxone (idebenone) a positive scientific...

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Learning Zones

An epgonline.org Learning Zone (LZ) is an area of the site dedicated to providing detailed self-directed medical education about a disease, condition or procedure.

Acute and Advanced Heart Failure

What are the most effective treatments for acute heart failure? Can you define advanced heart failure? Discover here...

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Hypogonadism

Epidemiology, pathophysiology, diagnosis/treatment guidelines, recent publication summaries and more

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Oral Anticoagulation Reversal

Experts discuss the use of non-vitamin K oral anticoagulants in the treatment and prevention of stroke, deep vein thrombosis and pulmonary embolism in atrial fibrillation patients

Visit Oral Anticoagulation Reversal


 

Guidelines

American Association of Clinical Endocrinologists and American College of Endocrinology guidelines for management of dyslipidemia and prevention of atherosclerosis.

The development of these guidelines is mandated by the American Association of Clinical Endocrinologists (AACE) Board of Directors and American College of Endocrinology (ACE) Board of Trustees.

2016 ESC/EAS guidelines for the management of dyslipidaemias

Guidelines summarize and evaluate all available evidence on a particular issue at the time of the writing process, with the aim of assisting health professionals in selecting the best management strategies for an individual patient.

2016 European Guidelines on cardiovascular disease prevention in clinical practice

The present guidelines represent an evidence-based consensus of the 6th European Joint Task Force  involving 10 professional societies.This document has...

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Journal articles

Left Ventricular Assist Device as a Bridge to Recovery for Patients With Advanced Heart Failure.

Left ventricular assist devices (LVADs) have been used as an effective therapeutic option in patients with advanced heart failure, either as a bridge to transplantation, as destination therapy, or in some patients, as a bridge to recovery.

Human ventricular unloading induces cardiomyocyte proliferation.

The adult mammalian heart is incapable of meaningful regeneration after substantial cardiomyocyte loss, primarily due to the inability of adult cardiomyocytes to divide.

Long-Term Use of a Left Ventricular Assist Device for End-Stage Heart Failure

Implantable left ventricular assist devices have benefited patients with end-stage heart failure as a bridge to cardiac transplantation, but their long-term use for the purpose of enhancing survival and the quality of life has not been evaluated.

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Clinical trials

Levosimendan Compassionate Use in Pediatric Patients With Advanced Decompensated Heart Failure

Open label study of levosimendan; planned comparison for effectiveness and safety to historic matched case controls from...

The Neuroprotective Effects of Dexmedetomidine During Brain Surgery

Dexmedetomidine (DEX) is a Alpha-2 specific agonist, is a common ICU sedation medication. In brain tumor resection craniotomy, it is proven to be effective in improving postoperative hypertension and...

A Trial Investigating the Cardiovascular Safety of Oral Semaglutide in Subjects With Type 2 Diabetes (PIONEER 6)

This trial is conducted globally. The aim of the trial is to investigate the cardiovascular safety of oral semaglutide in...

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Blog Posts

Hugh Harvey

Metrics Madness

You shouldn't judge a book by its cover. That much is true, but it's also common sense not to judge a book by measuring the whiteness of its pages, or the amount of hamsters you can place on it. So why do we measure the fabulous NHS with nonsense metrics?

Dr Sarah Brewer

Would Your Hypertensive Patients Benefit From Garlic?

Would you consider recommending garlic tablets for patients with hypertension? Either instead of initiating monotherapy, or as an adjunct to current medication if they remained poorly controlled? The evidence for benefit is growing… 

Peter English

The advance decision not to attempt cardiopulmonary resuscitation

Decisions to start cardiopulmonary resuscitation (CPR), or to decide in advance to issue a "do not attempt (cardiopulmonary) resuscitation" (DNAR) notice have always been a hot topic in clinical medicine. It may have become even more so since a recent (June 2014) court decision. This post discusses some of the issues and legalities around DNAR decisions.

CME

What's new in chronic heart failure

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Step by step: A guide to diagnosing heart failure

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Palliative care in patients with heart failure

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