10 Results

First results on survival from a large Phase 3 clinical trial of an autologous dendritic cell vaccine in newly diagnosed glioblastoma.

This Phase 3 trial evaluates the addition of an autologous tumor lysate-pulsed dendritic cell vaccine (DCVax®-L) to standard therapy for newly diagnosed glioblastoma.

Preclinical drug screen reveals topotecan, actinomycin D, and volasertib as potential new therapeutic candidates for ETMR brain tumor patients.

Background: Embryonal tumor with multilayered rosettes (ETMR) is a rare and aggressive embryonal brain tumor that solely occurs in infants and young children and has only recently been recognized as a separate brain tumor entity...

Goal-directed fluid restriction during brain surgery: a prospective randomized controlled trial.

The value of goal-directed fluid therapy in neurosurgical patients, where brain swelling is a major concern, is unknown.

Goal-directed fluid restriction during brain surgery: a prospective randomized controlled trial.

The value of goal-directed fluid therapy in neurosurgical patients, where brain swelling is a major concern, is unknown.

Goal-directed fluid restriction during brain surgery: a prospective randomized controlled trial.

The value of goal-directed fluid therapy in neurosurgical patients, where brain swelling is a major concern, is unknown.

Molecularly targeted drugs plus radiotherapy and temozolomide treatment for newly diagnosed glioblastoma: A meta-analysis and systematic review.

Glioblastoma (GBM) is the most common primary malignant brain tumor that nearly always results in a bad prognosis.

Histone deacetylase 6 inhibition enhances oncolytic viral replication in glioma.

Oncolytic viral (OV) therapy, which uses genetically engineered tumor-targeting viruses, is being increasingly used in cancer clinical trials due to...

Anti-tumor activity of phenoxybenzamine hydrochloride on malignant glioma cells.

Phenoxybenzamine hydrochloride (PHEN) is a selective antagonist of both α-adrenoceptor and calmodulin that exhibits anticancer properties. The aim of this...

A New Epigenetic Mechanism of Temozolomide Action in Glioma Cells.

Temozolomide (TMZ) is an oral alkylating chemotherapeutic agent that prolongs the survival of patients with glioblastoma (GBM). Despite that high...