This randomised multicentre trial aimed to establish whether there was a difference in INR reversal with either fresh frozen plasma or prothrombin complex concentrate in patients on vitamin K antagonist presenting with intracranial haemorrhage.
The incidence of geriatric traumatic brain injury (TBI) is increasing throughout the United States, with many of these patients taking anticoagulation (AC) medication.
Thromboelastometry (TEM)-guided haemostatic therapy with fibrinogen concentrate and prothrombin complex concentrate (PCC) in trauma patients may reduce the need for transfusion of red blood cells (RBC) or...
Urgent reversal of warfarin is required for patients who experience major bleeding or require urgent surgery. Treatment options include the combination of vitamin K and coagulation factor replacement with either prothrombin complex concentrate (PCC) or fresh frozen plasma (FFP).
This review article examines the current evidence for reversal of non-vitamin K oral anticoagulants.
This retrospective study of 63 patients taking warfarin who presented at a level 1 trauma centre and required emergency neurological procedures attempts to determine the difference in thrombotic complication rate following anticoagulation reversal with prothrombin complex concentrate (PCC) or fresh frozen plasma (FFP).
This study explored the change in risk of thromboembolism in patients randomised to receive either 4-factor prothrombin complex concentrate or fresh frozen plasma, using pooled data from two studies.
Review our recent article 'Reversal of warfarin-associated major haemorrhage: activated prothrombin complex concentrate versus 4-factor prothrombin complex concentrate.
Effective treatment of trauma-induced coagulopathy is important; however, the optimal therapy is still not known. We aimed to compare the efficacy of first-line therapy using fresh frozen plasma (FFP) or coagulation...
The use of PCC for reversing coagulopathy in multiply injured patients with pelvic and/or lower extremity fractures remains unclear. This study assesses the efficacy of PCC for reversing coagulopathy in this group of patients.