This site is intended for healthcare professionals
Journals
  • Home
  • /
  • Journals
  • /
  • Psoriasis
  • /
  • Efficacy and safety of ixekizumab for the treatmen...
Journal

Efficacy and safety of ixekizumab for the treatment of moderate-to-severe plaque psoriasis: Results through 108 weeks of a randomized, controlled phase 3 clinical trial (UNCOVER-3)

Read time: 1 mins
Published:1st Nov 2017
Author: Blauvelt A, Gooderham M, Iversen L, Ball S, Zhang L, Agada NO et al.
Availability: Free full text
Ref.:J Am Acad Dermatol. 2017 Nov;77(5):855-862.
DOI:10.1016/j.jaad.2017.06.153
Efficacy and safety of ixekizumab for the treatment of moderate-to-severe plaque psoriasis: Results through 108 weeks of a randomized, controlled phase 3 clinical trial (UNCOVER-3)


Background:
Ixekizumab, a high-affinity monoclonal antibody that selectively targets interleukin 17A, is efficacious in treating moderate-to-severe plaque psoriasis through 60 weeks.

Objective: To evaluate the efficacy and safety of ixekizumab through 108 weeks of treatment in UNCOVER-3.

Methods: Patients (N = 1346) were randomized 2:2:2:1 to 80 mg ixekizumab every 2 or 4 weeks, 50 mg etanercept twice weekly, or placebo. At week 12, patients switched to ixekizumab every 4 weeks during a long-term extension (LTE) period. Efficacy data were summarized using as-observed, multiple imputation (MI), and modified MI (mMI) methods.

Results: For patients (N = 385) receiving the recommended dose (ixekizumab every 2 weeks on weeks 0-12 and every 4 weeks during LTE), the 108-week as-observed, MI, and mMI response rates were 93.4%, 88.3%, and 83.6%, respectively, for patients achieving ≥75% improvement from baseline in the Psoriasis Area and Severity Index, and the 108-week as-observed, MI, and mMI response rates were 82.6%, 78.3%, and 74.1%, respectively, for patients with a static Physician's Global Assessment score of 0 or 1. During LTE, 1077 (84.5%) patients reported ≥1 treatment-emergent adverse event, and 85% were mild or moderate in severity. Discontinuation because of adverse events occurred in 6.4% of patients.

Limitations: There was no comparison treatment group after week 12.

Conclusion: Ixekizumab is well tolerated and demonstrates persistent efficacy through 108 weeks.


Read abstract on library site    Access full article