This site is intended for healthcare professionals
Journals
  • Home
  • /
  • Journals
  • /
  • Leukaemia
  • /
  • Chronic lymphocytic leukaemia: the role of T cells...
Journal

Chronic lymphocytic leukaemia: the role of T cells in a B cell disease

Read time: 1 mins
Published:2nd Apr 2019
Author: Man S, Henley P.
Availability: Pay for access, or by subscription
Ref.:Br J Haematol. 2019.
DOI:10.1111/bjh.15918

Chronic lymphocytic leukaemia (CLL) has long been thought to be an immunosuppressive disease and abnormalities in T-cell subset distribution and function have been observed in many studies. However, the role of T cells (if any) in disease progression remains unclear and has not been directly studied. This has changed with the advent of new therapies, such as chimeric antigen receptor-T cells, which actively use retargeted patient-derived T cells as “living drugs” for CLL. However complete responses are relatively low (~26%) and recent studies have suggested the differentiation status of patient T cells before therapy may influence efficacy. Non-chemotherapeutic drugs, such as idelalisib and ibrutinib, also have an impact on T cell populations in CLL patients. This review will highlight what is known about T cells in CLL during disease progression and after treatment, and discuss the prospects of using T cells as predictive biomarkers for immune status and response to therapy.

 

Read abstract on library site

Access full article