8,450 Results

Different endotypes and phenotypes drive the heterogeneity in severe asthma.

The identification of sputum eosinophilia indicating corticosteroid responsiveness in subjects with severe asthma heralded the beginning of phenotyping asthmatic subjects based on airways inflammation.

Targeting NLRP3 Inflammasome Activation in Severe Asthma.

Severe asthma (SA) is a chronic lung disease characterized by recurring symptoms of reversible airflow obstruction, airway hyper-responsiveness (AHR), and inflammation that is resistant to currently employed treatments.

Meta-analysis of vitamin D and lung function in patients with asthma.

Background: There is growing literature suggesting a link between vitamin D and asthma lung function, but the results from systematic reviews are conflicting. We conducted this meta-analysis to investigate the relation between...

Current state and future prospect of the therapeutic strategy targeting cysteinyl leukotriene metabolism in asthma.

Asthma is an allergic disorder with dominant type 2 airway inflammation, and its prevalence is increasing worldwide. Inhalation of corticosteroids is the primary treatment for asthma along with add-on drugs, including...

The Effects of Obesity in Asthma.

Purpose of Review: Rising costs and increasing morbidity makes the identification and treatment of high-risk asthma phenotypes important. In this review, we outline the complex relationship between obesity and asthma.

Asthma exacerbation trajectories and their predictors in children with incident asthma.

Objective: To identify trajectories of asthma exacerbation and predictors of these trajectories in children with incident asthma.

Role of IL-17 in asthma pathogenesis and its implications for the clinic.

Areas covered: Severe asthmatics represent a distinct phenotype with their mixed pattern of neutrophilic-eosinophilic infiltration and glucocorticoid insensitivity making them refractory to currently available therapies.

Primary care of asthma: new options for severe eosinophilic asthma.

This paper reviews asthma assessment in primary care and describes the pathophysiology, clinical characteristics and new targeted treatments available for patients with severe eosinophilic asthma.

Nocturnal asthma is affected by genetic interactions between RORA and NPSR1.

Background: Neuropeptide S Receptor 1 (NPSR1) and Retinoid Acid Receptor‐Related Orphan Receptor Alpha (RORA) interact biologically, are both known candidate genes for asthma, and are involved in controlling...

Migraine is first cause of disability in under 50s: will health politicians now take notice?

If it were needed, more evidence of the disconcerting under-treatment of headache disorders has come from the Eurolight study [1]. The topic is not new. Twenty years ago, the International and American Headache Societies jointly voiced ...

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