Horizons

Opinion & insight from our Clinical Steering Group

Horizons, led by a team of experts from our Clinical Steering Group, is a series of scientific articles which take a deep dive into the emerging trends in the healthcare landscape, kickstarting a dialogue about how treatments and strategies should be best implemented for the benefit of patients.

We're discussing new treatments, especially in oncology, and how they are set to disrupt healthcare practices in the coming years. Some of the topics we'll be tackling include:

  • Antibody-drug conjugates

  • Immuno-oncology

  • Oral proteasome inhibitors – multiple myeloma

  • CDK 4&6

  • Biosimilars – both as a class and specifics

  • PARP inhibitors

  • CAR-T

What's on the Horizon?

Marshall Pearce

Left ventricular assist devices – A viable therapeutic option for heart failure?

Posted 1 month ago

Alongside a pharmacological strategy to aid myocardial recovery, LVADs may prove to have a significant role to play in the ever-growing problem of heart failure. Although LVADs are not new onto the scene, the advance of technology – smaller, more efficient devices with better reliability and potentially transcutaneous power transfer – means we may be on the cusp of seeing many more deployed to tackle heart failure.

Marshall Pearce

Antibody-drug conjugates (ADCs)

Posted 3 months ago

Over the past couple of decades, there have been advances in a class of drugs which for a long time was purely theoretical: antibody-drug conjugates (ADCs). The concept underlying ADCs is elegant – what if it were possible to ‘target’ particular groups of cells with a cytotoxic agent, rather than exposing every cell of the body to it?

Marshall Pearce

Cancer immunotherapies

Posted 3 months ago

It was the winner of the 1908 Nobel prize for medicine, Paul Ehrlich, who is first credited with discussing the concept of a “magic bullet”, able to target specific cells without damaging healthy tissue. With the advent of immunotherapy, as well as antibody-drug conjugates, we are beginning to realise this vision.

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