Varicella zoster virus (VZV) infections – herpes zoster Valtrex is indicated for the treatment of herpes zoster (shingles) and ophthalmic zoster in immunocompetent adults (see sections 4.4). Valtrex is indicated for the treatment of herpes zoster in adult patients with mild or moderate immunosuppression (see section 4.4). Herpes simplex virus (HSV) infections Valtrex is indicated • for the treatment and suppression of HSV infections of the skin and mucous membranes including: - treatment of first-episode of genital herpes in immunocompetent adults and adolescents and in immunocompromised adults - treatment of recurrences of genital herpes in immunocompetent adults and adolescents, and in immunocompromised adults - suppression of recurrent genital herpes in immunocompetent adults and adolescents and in immunocompromised adults • Treatment and suppression of recurrent ocular HSV infections in immunocompetent adults and adolescents and in immunocompromised adults (see section 4.4) Clinical studies have not been conducted in HSV-infected patients immunocompromised for other causes than HIV-infection (see section 5.1). Cytomegalovirus (CMV) infections Valtrex is indicated for the prophylaxis of CMV infection and disease following solid organ transplantation in adults and adolescents (see section 4.4)