Data from EMA (European Medicines Agency) - Curated by EPG Health - Last updated 09 August 2017
- adult patients with newly-diagnosed glioblastoma multiforme concomitantly with radiotherapy (RT) and subsequently as monotherapy treatment.
- children from the age of three years, adolescents and adult patients with malignant glioma, such as glioblastoma multiforme or anaplastic astrocytoma, showing recurrence or progression after standard therapy.
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Adult Study: ABT-414 Alone or ABT-414 Plus Temozolomide vs. Lomustine or Temozolomide for Recurrent Glioblastoma Pediatric Study: Evaluation of ABT-414 in Children With High Grade Gliomas (INTELLANCE 2)
This study is to evaluate the efficacy and safety of ABT-414 alone or with temozolomide versus temozolomide or lomustine alone in participants with recurrent glioblastoma multiforme.
Added 11 months ago
Dexmedetomidine (DEX) is a Alpha-2 specific agonist, is a common ICU sedation medication. In brain tumor resection craniotomy, it is proven to be effective in improving postoperative hypertension and...
Added 1 year ago
The trial includes i) the evaluation of the efficacy of a treatment strategy, designed as a phase II trial, and...
Added 5 years ago
Phase I / II study of sequential high-dose chemotherapy with stem cell support in children younger than 5 years of age with high-risk medulloblastoma
Phase II: To assess the efficacy in terms of Event Free Survival (EFS) of the strategy intended to treat children...
Added 5 years ago
Preclinical drug screen reveals topotecan, actinomycin D, and volasertib as potential new therapeutic candidates for ETMR brain tumor patients.
Background: Embryonal tumor with multilayered rosettes (ETMR) is a rare and aggressive embryonal brain tumor that solely occurs in infants and young children and has only recently been recognized as a separate brain tumor entity...
Added 2 months ago
Oncolytic viral (OV) therapy, which uses genetically engineered tumor-targeting viruses, is being increasingly used in cancer clinical trials due to...
Added 2 years ago
Temozolomide (TMZ) is an oral alkylating chemotherapeutic agent that prolongs the survival of patients with glioblastoma (GBM). Despite that high...
Added 2 years ago
The ESMO Clinical Practice Guidelines (CPG) are intended to provide the user with a set of recommendations for the best...
Added 3 years ago
Venous thromboembolism (VTE) and bleeding are serious complications of cancer and its treatment. A recent survey of UK paediatric haematologists and oncologists identified a broad variety of practice in the management of issues...
Added 5 days ago
EANO–ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up of patients with leptomeningeal metastasis from solid tumours
These EANO-ESMO joint recommendations for the diagnosis and treatment of leptomeningeal metastasis from solid cancers represent the first European guideline initiative on this topic.
Added 5 months ago
The objective is to formulate clinical practice guidelines for treating Cushing's syndrome.
Added 6 months ago
|Agency product number||EMEA/H/C/001126|
|Date First Approved||28-01-2010|
|Type||Medicinal product subject to restricted medical prescription|
|Marketing authorisation holder||Teva B.V.|