Data from EMC - Curated by EPG Health - Last updated 23 August 2016

Indication(s)

Antimitotic and cytotoxic

Recommended for certain types of cancer in combination with other drugs or after primary therapy has failed. It has been successfully used to improve subjective and objective symptoms in a wide range of neoplastic conditions.

1. As a single agent in the treatment of superficial bladder cancer. In addition it has been shown that post-operative instillations of Mitomycin-C can reduce recurrence rates in newly diagnosed patients with superficial bladder cancer.

2. As a single agent and in combination with other drugs in metastatic breast cancer.

3. In combination with other agents in advanced squamous cell carcinoma of the uterine cervix.

4. It shows a degree of activity as part of combination therapy in carcinoma of the stomach, pancreas and lung (particularly non-small cell).

5. It shows a degree of activity as a single agent and in combination in liver cancer when given by the intra-arterial route.

6. It has a possible role in combination with other cytotoxic drugs in colo-rectal cancer.

7. It shows a degree of activity as a single agent or part of combination therapy in cancer of the head and neck.

8. It shows a degree of activity as a single agent in cancer of the prostate.

9. It has a possible role in skin cancer.

10. It has a degree of activity in leukaemia and non-solid tumours.

11. It has a possible role in sarcomas.

12. It has been successfully used in combination with surgery, pre-operatively (oesophageal squamous cell carcinoma) and post-operatively (gastric cancer).

13. It has shown to be effective when used in combination with radiotherapy.

 

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