Pro-Epanutin is indicated in adults and children aged 5 years and older: • for the control of status epilepticus of the tonic-clonic (grand mal) type (see section 4.2). • for prevention and treatment of seizures occurring in connection with neurosurgery and/or head trauma. • as substitute for oral phenytoin if oral administration is not possible and/or contra-indicated.
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Control of tonic-clonic seizures (grand mal epilepsy), partial seizures (focal including temporal lobe) or a combination of these, and for the prevention and treatment of seizures occurring during or following neurosurgery and/or severe head injury. Epanutin has also been employed in the treatment of trigeminal neuralgia but it should only be used as second line therapy if carbamazepine is ineffective or patients are intolerant to carbamazepine.
The prevention and treatment of candidal infections of the oral cavity, oesophagus and intestinal tract. The suspension provides effective prophylaxis against oral candidosis in those born of mothers with vaginal candidosis.
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Anticoagulation in adult patients with heparin-induced thrombocytopenia type II who require parenteral antithrombotic therapy. The diagnosis should be confirmed by the HIPAA (heparin induced platelet activation assay) or an equivalent test. However, such confirmation must not delay the start of treatment.
Supportive treatment where standard surgical techniques are insufficient - for improvement of hemostasis (see section 5.1) - as a tissue glue to promote adhesion/sealing, or as suture support: - in gastrointestinal anastomoses - in neurosurgery where contact with cerebro-spinal fluid or dura mater may occur - For mesh fixation in hernia repair, as an alternative or adjunct to sutures or staples.
For the treatment of acute hypotension due to loss of vasoconstrictor tone as may occur during spinal anaesthesia and as an adjunct to accepted remedial procedures.