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Added 4 days ago Drug news

New data from Phase 1/II HGB-206 study of LentiGlobin gene therapy in patients with sickle cell disease.-bluebird bio.

bluebird bio, Inc. announced new data from patients in Group C of its ongoing Phase 1/II HGB-206 study of the...

Added 4 days ago Drug news

Results of Phase III trials NORTHSTAR-2 and NORTHSTAR-3 of LentiGlobin gene therapy to treat transfusion-dependent beta-thalassemia. bluebirdbio.

bluebird bio, Inc. announced new data from the Phase III Northstar-2 (HGB-207) and Northstar-3 (HGB-212) clinical studies of its investigational...

Added 6 days ago Drug news

Positive results from BELIEVE study of luspatercept for the treatment of adults with beta-thalassemia-associated anemia. Celgene + Acceleron.

Celgene Corporation and Acceleron Pharma Inc.announced results from a pivotal, phase III trial (BELIEVE) evaluating the safety and efficacy of...

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Learning Zones

An epgonline.org Learning Zone (LZ) is an area of the site dedicated to providing detailed self-directed medical education about a disease, condition or procedure.

Chronic Lymphocytic Leukaemia (CLL)

Chronic Lymphocytic Leukaemia (CLL)

Refine your knowledge of chronic lymphocytic leukaemia (CLL) with information on pathophysiology, diagnosis, treatment options and more

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Oral Anticoagulation Reversal

Oral Anticoagulation Reversal

Experts discuss the use of non-vitamin K oral anticoagulants in the treatment and prevention of stroke, deep vein thrombosis and pulmonary embolism in atrial fibrillation patients.

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Guidelines

Sickle cell disease: managing acute painful episodes in hospital

This guideline covers managing acute painful sickle cell episodes in children, young people and adults who present at hospital, from presentation until when they are discharged.

Added 6 years ago

Management of Sickle Cell Disease in Pregnancy

The purpose of this guideline is to describe the management of pregnant women with sickle cell disease (SCD). It will include preconceptual screening and antenatal, intrapartum and postnatal management.

Added 7 years ago

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Journal articles

Venous Thromboembolism Incidence in the Cooperative Study of Sickle Cell Disease

Background: Venous thromboembolism (VTE) has been recently recognized as a complication of sickle cell disease (SCD); however, the incidence of...

Added 4 years ago

Treatment of the acute sickle cell vaso-occlusive crisis in the Emergency Department: a Brazilian method of switching from intravenous to oral morphine

Objectives: Describe the treatment of patients with vaso-occlusive crises (VOC) in a Brazilian emergency department (ED) and the successful switch...

Added 4 years ago

Genetic variation in CD36, HBA, NOS3 and VCAM1 is associated to chronic haemolysis level in sickle cell anaemia: a longitudinal study

Chronic haemolysis stands out as one of the hallmarks of sickle-cell anaemia, a clinically heterogeneous autosomal recessive monogenic anaemia. However,...

Added 5 years ago

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Clinical trials

A Study Evaluating the Efficacy and Safety of LentiGlobin BB305 Drug Product in Beta-Thalassemia Major and Sickle Cell Disease

This is a Phase 1/2, open label, safety, and efficacy study of the administration of LentiGlobin BB305 Drug Product to subjects with either beta-thalassemia major or severe sickle cell disease (SCD).

Added 5 years ago

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CME

Sickle cell anaemia

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