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Added 2 months ago Drug news

JEWEL study of lurasidone for the treatment of patients with schizophrenia met its primary endpoint.- Sumitomo Dainippon

Sumitomo Dainippon Pharma Co., Ltd. announced that topline results from a Phase III clinical study (JEWEL study, “this study”) evaluating...

Added 3 months ago Drug news

FDA accepts for review NDA for lumateperone to treat schizophrenia.-Intra-Cellular Therapies

Intra-Cellular Therapies announced that the FDA has accepted for review its New Drug Application (NDA) for lumateperone, an investigational agent...

Added 3 months ago Drug news

Phase III study of ALKS 3831 meets endpoints in schizophrenia.- Alkermes.

Alkermes announced positive topline results from ENLIGHTEN-2, a pivotal phase III study of ALKS 3831 (olanzapine/samidorphan), an investigational, novel, once-daily,...

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Chronic Lymphocytic Leukaemia (CLL)

Chronic Lymphocytic Leukaemia (CLL)

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Transplantation

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Guidelines

British Association for Psychopharmacology consensus guidance on the use of psychotropic medication preconception, in pregnancy and postpartum 2017

Decisions about the use of psychotropic medication in pregnancy are an ongoing challenge for clinicians and women with mental health problems, owing to the uncertainties around risks of the illness itself to mother and fetus/infant...

Added 1 year ago

Psychosis and schizophrenia in children and young people: Recognition and management

This guideline is concerned with the recognition and management of psychosis and schizophrenia in children and young people up to...

Added 6 years ago

World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for Biological Treatment of Schizophrenia. Part 3: Update 2015 Management of special circumstances: Depression, Suicidality, substance use disorders and pregnancy and lactation

This third part of the updated guidelines covers the management of the following specific treatment circumstances: comorbid depression, suicidality, various comorbid substance use disorders (legal and illegal drugs), and pregnancy and lactation.

Added 3 years ago

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Journal articles

Effectiveness of paliperidone long-acting injection in clinical practice.

Background: The efficacy of the long-acting injectable formulation of the antipsychotic paliperidone (paliperidone palmitate) has been investigated in randomized controlled trials.

Added 8 months ago

Efficacy and safety profile of paliperidone palmitate injections in the management of patients with schizophrenia: an evidence-based review.

This review focuses on paliperidone palmitate, the long-acting injectable (LAI) formulation of paliperidone. After considering the pharmacology of paliperidone palmitate, we review the randomized controlled trials...

Added 8 months ago

Dosing strategies for switching from oral risperidone to paliperidone palmitate: Effects on clinical outcomes.

Introduction: There are currently no guidelines for switching patients from oral risperidone to paliperidone palmitate (Invega Sustenna®). Furthermore, the paliperidone long-acting injectable (LAI) package...

Added 8 months ago

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Clinical trials

Pharmacologic Treatment of Acute Episode of Schizophrenia: a Real World Study

This study attempts to observe the effectiveness and safety of aripiprazole in hospitalized patients with acute schizophrenia episode, and to compare the different drug regimens that may be involved in order to clarify the characteristics...

Added 1 year ago

Study to Evaluate Safety & Efficacy of NaBen® as Add-on Treatment for Schizophrenia in Adults

The proposed Phase IIb/III study is designed to evaluate the safety and efficacy of NaBen® in improving the symptoms of schizophrenia in adults. NaBen® is granted Breakthrough Therapy Designation by US FDA as add-on treatment...

Added 1 year ago

Efficacy and Safety of Adjunctive Pimavanserin for the Treatment of Schizophrenia (ENHANCE-1)

To evaluate the efficacy and safety of adjunctive pimavanserin compared with adjunctive placebo in the treatment of schizophrenia

Added 1 year ago

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Bob Bury

I’m a retired radiologist, and I keep myself busy with hill-walking, fishing and medical journalism/blogging, but mostly I’m a provider of free healthcare for my grandchildren. I am also accredited by the British Humanist Association to officiate at non-religious funerals: http... Read more

Community Mental Health Provision then and now - is all progress positive?

Bob Bury muses on the state of modern mental healthcare. Instead of asylums, patients are now part of the community. But what of those who fall through the cracks? How can GPs help patients who need emergency mental health care? Can we learn anything from the methods of the past? Are three letter acronyms helpful? Examining the politics and hurdles of the UK's modern Community Mental Health provision, Bob Bury questions what UK healthcare professionals can do better and how things should change.

CME

Guidance update: latest NICE guidelines on bipolar disorder, psychosis and schizophrenia in children

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Hallucinations - red flag symptoms

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