Latest news articles

Added 8 days ago Drug news

Interim analysis of REPAIR study of Opsumit shows improved heart function in pulmonary arterial hypertension

Actelion Pharmaceuticals announced an interim analysis from the Right vEntricular Remodeling in Pulmonary ArterIal hypeRtension (REPAIR) study of Opsumit (macitentan)...

Added 1 month ago Drug news

Phase III FREEDOM-EV study of Orenitram meets primary endpoint in pulmonary arterial hypertension.- United Therapeutics

United Therapeutics announced that key data from the phase III FREEDOM-EV study of Orenitram (treprostinil) extended-release tablets shows that the...

Added 2 months ago Drug news

Positive phase III INSPIRE study of LIQ 861 to treat pulmonary arterial hypertension. Liquidia Technologies

Liquidia Technologies, Inc.reported positive interim safety data from its open-label, multicenter Phase III clinical trial (INSPIRE) evaluating LIQ 861 an...

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Learning Zones

An epgonline.org Learning Zone (LZ) is an area of the site dedicated to providing detailed self-directed medical education about a disease, condition or procedure.

Cardiovascular Metabolism Knowledge Centre

Cardiovascular Metabolism Knowledge Centre

The Cardiovascular Metabolism Knowledge Centre is an information hub providing expert insight into the management of hypertension and type 2 diabetes. This Knowledge Centre contains a wealth of scientific video content offering insights and opinion from some of the leading experts in the field.

Oral Anticoagulation Reversal

Oral Anticoagulation Reversal

Experts discuss the use of non-vitamin K oral anticoagulants in the treatment and prevention of stroke, deep vein thrombosis and pulmonary embolism in atrial fibrillation patients.

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Guidelines

British Thoracic Society Guideline for the initial outpatient management of pulmonary embolism (PE)

The British Thoracic Society (BTS) Guideline for the initial OP management of PE provides guidance on how to risk-stratify patients with suspected and confirmed PE and subsequently manage them in an OP or ambulatory care setting.

Added 9 months ago

Venous thromboembolism in over 16s: reducing the risk of hospital-acquired deep vein thrombosis or pulmonary embolism

VTE is a condition in which a blood clot (thrombus) forms in a vein. It most commonly occurs in the...

Added 9 years ago

BSH Guideline: management of thrombotic and haemostatic issues in paediatric malignancy

Venous thromboembolism (VTE) and bleeding are serious complications of cancer and its treatment. A recent survey of UK paediatric haematologists and oncologists identified a broad variety of practice in the management of issues...

Added 1 year ago

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Journal articles

Performance of idarucizumab as antidote of dabigatran in daily clinical practice.

Aims: Because practice-based data on the usage of idarucizumab for urgent dabigatran reversal is unavailable, we evaluated the appropriateness of idarucizumab usage, its haemostatic effectiveness and clinical outcomes.

Added 3 days ago

Reversal strategies in patients treated with direct oral anticoagulants.

The aim of this review is to summarize recent study data and recommendations on nonspecific and specific DOAC reversal strategies and to present the current evidence.

Added 3 days ago

Intravenous Levosimendan and Vasopressin in New-Onset Acute Pulmonary Hypertension After Weaning from Cardiopulmonary Bypass.

Objective: A novel treatment with intravenous levosimendan and vasopressin for new-onset acute pulmonary hypertension after weaning from cardiopulmonary bypass is described.

Added 5 months ago

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Clinical trials

A Study to Investigate Different Doses of BAY1213790 to Prevent Blood Clots in Patients Undergoing Elective Total Knee Replacement Surgery (FOXTROT)

This study is to compare the study drug BAY1213790 to existing therapies, ie Enoxaparin or Apixaban for the prevention of blood clotting and safety in patients undergoing total knee arthroplasty (TKA).

Added 1 year ago

Reduced-dosed Rivaroxaban in the Long-term Prevention of Recurrent Symptomatic VTE(Venous Thromboembolism) (EinsteinChoice)

This is a multicenter, randomized, double-blind, event-driven, superiority study for efficacy.
Patients with confirmed symptomatic DVT (Deep Vein Thrombosis) or PE (Pulmonary embolism)...

Added 6 years ago

Extended Venous Thromboembolism Prophylaxis Comparing Rivaroxaban to Aspirin Following Total Hip and Knee Arthroplasty (EPCAT II)

In this study the investigators want to look at whether using aspirin instead of rivaroxaban (after initial treatment with rivaroxaban) works as well at preventing blood clots while also reducing risk of bleeding...

Added 1 year ago

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David Warriner

Dr David R Warriner is currently a Cardiology Registrar practising in South Yorkshire. Dr Warriner's clinical and research interests include heart failure, exercise physiology, physiological modelling, sports medicine and medical education. In his free time, Dr Warriner loves reading ... Read more

What is Overdiagnosis?

Overdiagnosis is the diagnosis of disease that will cause neither morbidity nor mortality during a patient’s lifetime. Doctors are trained to listen, examine, test, diagnose and treat patients, but we are not warned of the possible dangers of “diseases”, the diagnosis of which will not benefit the patient and may also lead to harm. I would argue that the Hippocratic oath, in particular “Primum non nocere” (first, do no harm) should be at the forefront of every clinician’s mind when seeing patients.