Other hereditary or degenerative neurological disorders

This collection of diseases encompasses a wide range of conditions, categorised by their symptomatic impact upon the neurological system. Pathogenesis and epidemiology are

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Latest news articles

Added 15 hours ago Drug news

Biogen announces a new trial DEVOTE to evaluate a higher dose of Spinraza for patients with spinal muscular atrophy.

Biogen Inc.has announced updates to the Spiraza (nusinersen) clinical development program including the initiation of a new global clinical trial,...

Added 2 days ago Drug news

AveXis/Novartis presents data continuing to show significant benefit of Zolgensma in prolonging event-free survival up to 5 years of age in spinal muscular atrophy (SMA)Type I .

AveXis, a Novartis company, announced that new interim data from the Phase III SPR1NT trial in pre-symptomatic patients as well...

Added 30 days ago Drug news

Fosmetpantotenate fails in Phase III FORT study to treat pantothenate kinase-associated neurodegeneration

Retrophin, Inc. announced that the Phase III FORT Study evaluating the safety and efficacy of fosmetpantotenate compared to placebo in...

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Learning Zones

An epgonline.org Learning Zone (LZ) is an area of the site dedicated to providing detailed self-directed medical education about a disease, condition or procedure.

EPNS 2019 Congress Highlights

EPNS 2019 Congress Highlights

The epgonline.org team is creating daily reports from the 13th European Paediatric Neurology Society (EPNS) Congress, held in Athens, Greece from 17th to 21st September 2019, to bring you coverage of cutting-edge science and advances in clinical care across all fields of paediatric neurology. 

Migraine Knowledge Centre

Migraine Knowledge Centre

The Migraine Knowledge Centre features latest research on the prevalence and impact of migraine, the proposed neurological basis of the condition (and how this is being translated into new and exciting drug therapies), as well as current patient care strategies collated from headache organisations worldwide.

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Guidelines

Suspected neurological conditions: recognition and referral

This guideline covers the initial assessment of symptoms and signs that might indicate a neurological condition. It helps non-specialist healthcare professionals to identify people who should be offered referral for specialist investigation.

Added 1 month ago

Motor neurone disease: assessment and management

This guideline covers assessing and managing motor neurone disease (MND). It aims to improve care from the time of diagnosis, and covers information and support, organisation of care, managing symptoms and preparing for end of life care.

Added 1 month ago

Spasticity in under 19s: management

This guideline covers managing spasticity and co-existing motor disorders and their early musculoskeletal complications in children and young people (from birth up to their 19th birthday) with non-progressive brain disorders.

Added 7 years ago

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Journal articles

Nusinersen initiated in infants during the presymptomatic stage of spinal muscular atrophy: Interim efficacy and safety results from the Phase 2 NURTURE study

Spinal muscular atrophy (SMA) is a neurodegenerative disease associated with severe muscle atrophy and weakness in the limbs and trunk. We report interim efficacy and safety outcomes as of March 29, 2019 in 25 children with...

Added 3 days ago

The diagnosis of progressive supranuclear palsy: current opinions and challenges.

Introduction: Progressive supranuclear palsy (PSP) is associated with microtubule-associated protein tau dysfunction. Originally thought to result in a syndrome of atypical Parkinsonism, vertical supranuclear gaze palsy...

Added 3 months ago

Advances in progressive supranuclear palsy: new diagnostic criteria, biomarkers, and therapeutic approaches.

Progressive supranuclear palsy (PSP), previously believed to be a common cause of atypical parkinsonism, is now recognised as a range of motor and behavioural syndromes that are associated with a characteristic 4-repeat tau neuropathology.

Added 3 months ago

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Clinical trials

Study of Nusinersen (BIIB058) in Participants With Spinal Muscular Atrophy

The primary objective of the study is to examine the clinical efficacy of nusinersen administered intrathecally at higher doses to participants with spinal muscular atrophy (SMA).

Added 3 days ago

Long-Term Follow-up Study for Patients From AVXS-101-CL-101 (START)

This is a long term, safety follow up study of patients in the AVXS-101-CL-101 gene replacement therapy clinical trial for SMA Type 1 delivering onasemnogene abeparvovec-xioi.

Added 5 days ago

Study of BIIB092 in Participants With Progressive Supranuclear Palsy (PASSPORT)

The Primary objective of the study is to evaluate the efficacy of BIIB092, compared to placebo, as measured by a change from baseline in the PSP Rating Scale (PSPRS) at Week 52 and to assess the safety and tolerability of BIIB092...

Added 3 months ago

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CME

Huntington's disease: clinical review

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MIMS Learning - Monthly Index of Medical Specialities
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Cerebral palsy

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MIMS Learning - Monthly Index of Medical Specialities
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Motor neurone disease: clinical review

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MIMS Learning - Monthly Index of Medical Specialities
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1
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1
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Search all CME for Other hereditary or degenerative neurological disorders