Latest news articles

Added 5 days ago Drug news

FDA grants accelerated approval for Galafold treatment of adults with a confirmed diagnosis of Fabry disease and an amenable galactosidase alpha gene (GLA) variant based on in vitro assay data.--Amicus Therapeutics.

Amicus Therapeutics has announced that the FDA has granted accelerated approval of Galafold (migalastat) 123 mg capsules. Galafold is an...

Added 24 days ago Drug news

New analyses from the APOLLO Phase III study of patisiran for the treatment of hereditary ATTR (hATTR) amyloidosis.

Alnylam Pharmaceuticals, Inc. announced that the Company presented new analyses from the APOLLO Phase III study of patisiran, an investigational...

Added 30 days ago Drug news

CAMELLIA-TIMI 61 outcomes trial of Belviq meets primary endpoint in obesity.- Eisai.

Eisai announced positive topline results from the CAMELLIA-TIMI 61 cardiovascular outcome trial, a 12,000 patient study of Belviq (lorcaserin HCl)...

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Learning Zones

An epgonline.org Learning Zone (LZ) is an area of the site dedicated to providing detailed self-directed medical education about a disease, condition or procedure.

Hyperammonaemia

Hyperammonaemia

Hyperammonaemia can result in serious neurological damage or death. Could you recognise the signs and symptoms?

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ALP Lab Assessment

ALP Lab Assessment

Discover an overview of hypophosphatasia and details required to facilitate the timely and accurate detection of low alkaline phosphatase.

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Guidelines

UK Commissioning guide: Massive Weight Loss Body Contouring

This document is about guidance for commissioning reconstructive procedures, post massive weight loss and is based on the best available evidence.

Added 2 months ago

Emergency management of acute hypercalcaemia in adult patients

Abnormalities of parathyroid function, bone resorption, renal calcium reabsorption or dihydroxylation of vitamin D may cause regulatory mechanisms to fail and serum calcium may rise.

Added 5 years ago

Acute Hypocalcaemia - for use in adult patients

Acute hypocalcaemia can be life threatening, necessitating urgent treatment. In severe cases, intravenous calcium forms the mainstay of initial therapy, but it is essential to ascertain the underlying cause and commence specific therapy...

Added 5 years ago

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Journal articles

Efficacy of High-Dose Liraglutide as an Adjunct for Weight Loss in Patients with Prior Bariatric Surgery.

We sought to determine the efficacy of high-dose liraglutide (3.0 mg once daily) in patients with prior bariatric surgery.

Added 15 days ago

Patisiran, an RNAi Therapeutic, for Hereditary Transthyretin Amyloidosis.

Background: Patisiran, an investigational RNA interference therapeutic agent, specifically inhibits hepatic synthesis of transthyretin.

Added 1 month ago

Burosumab: First Global Approval.

This article summarizes the milestones in the development of burosumab leading to its first global approval in the EU for XLH in paediatric patients.

Added 1 month ago

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Clinical trials

CARAT: Canagliflozin vs. placebo for post bariatric patients with persistent type 2 diabetes

This is a prospective, randomized clinical trial for patients with recurrent type 2 diabetes post-gastric bypass surgery that will compare a 6 month course of canagliflozin monotherapy vs. placebo on clinical outcomes of type 2 diabetes.

Added 1 year ago

Setmelanotide for the treatment of early-onset POMC deficiency obesity

The purpose of the study is to determine the effect of setmelanotide (RM-493) on weight and other factors in patients with pro-opiomelanocortin (POMC) deficiency obesity due to rare bi-allelic loss-of function POMC or PCSK1 genetic mutations.

Added 1 year ago

Division-less gastric bypass, step to decrease cost and early nightmare of bariateric surgery

The purpose of this study is to determine the efficacy of of gastric bypass without gastric division as a treatment for morbid obesity.

Added 1 year ago

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Alex Keen

Alex studied Biological Sciences at university before joining EPG Health in January 2017, where he works as a digital content manager and editor.

In his spare time, Alex enjoys relaxing with a cool pint in the company of good friends. 

ILC 2018 – Targetable pathways in liver disease: from identification to clinical application

A number of studies from the speakers at this year's ILC Basic Science Seminar are discussed here, focusing on targetable pathways in liver disease, covering pathway identification, potential drug targets and their clinical application.

CME

Obesity: clinical review

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MIMS Learning - Monthly Index of Medical Specialities
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The diagnostic value of hyperammonemia induced by the non-ischemic forearm exercise test

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BMJ Learning - British Medical Learning
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Obesity: a guide to prevention and management - putting NICE guidelines into practice

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BMJ Learning - British Medical Learning
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90
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