Melanomas of skin

Although it is one of the rarer forms of skin cancer, melanoma is responsible for a disproportionate amount of mortality. Its incidence has been increasing over time, and is

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Chronic Lymphocytic Leukaemia (CLL)

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Guidelines

Cutaneous melanoma

This guideline provides advice at all stages of the patient’s pathway of care, from primary prevention to early recognition, treatment and follow up.

Added 2 years ago

Cutaneous melanoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

Cutaneous melanoma is the most common type of melanoma, and UV exposure is one of the main risk factors.

Added 4 years ago

Melanoma: assessment and management

This guideline covers the assessment and management of melanoma (a type of skin cancer) in children, young people and adults. It aims to reduce variation in practice and improve survival.

Added 4 years ago

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Journal articles

Encorafenib plus binimetinib versus vemurafenib or encorafenib in patients with BRAF-mutant melanoma (COLUMBUS): a multicentre, open-label, randomised phase 3 trial.

Background: Combined BRAF-MEK inhibitor therapy is the standard of care for BRAF V600-mutant advanced melanoma. We investigated encorafenib, a BRAF inhibitor with unique target-binding properties...

Added 2 months ago

Adverse events associated with encorafenib plus binimetinib in the COLUMBUS study: incidence, course and management.

Background: Dual inhibition of the mitogen-activated protein kinase pathway with BRAF/MEK inhibitor (BRAFi/MEKi) therapy is a standard treatment for BRAFV600-mutant metastatic melanoma and has...

Added 2 months ago

Encorafenib in combination with binimetinib for unresectable or metastatic melanoma with BRAF mutations.

Areas covered: Encorafenib in combination with bimetinib offers a new approach that may offer benefits over existing BRAF/MEK inhibitor combinations.

Added 2 months ago

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Clinical trials

Efficacy Study of Nivolumab Compared to Ipilimumab in Prevention of Recurrence of Melanoma After Complete Resection of Stage IIIb/c or Stage IV Melanoma (CheckMate 238)

The purpose of this study is to determine whether nivolumab is better than ipilimumab to prevent recurrence of melanoma.

Added 1 year ago

Study Comparing Combination of LGX818 Plus MEK162 Versus Vemurafenib and LGX818 Monotherapy in BRAF Mutant Melanoma (COLUMBUS)

This is 2-part, randomized, open label, multi-center, parallel group, phase III study comparing the efficacy and safety of LGX818 plus MEK162 to vemurafenib and LGX818 monotherapy in patients with locally advanced...

Added 2 months ago

A Study of the BRAF Inhibitor Dabrafenib in Combination With the MEK Inhibitor Trametinib in the Adjuvant Treatment of High-risk BRAF V600 Mutation-positive Melanoma After Surgical Resection. (COMBI-AD)

This is a two-arm, randomized, double-blind Phase III study of dabrafenib in combination with trametinib versus two placebos in the adjuvant treatment of melanoma after surgical resection.

Added 8 years ago

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CME

Urgent referrals in dermatology

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Malignant melanoma: clinical review

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Developments in melanoma treatment

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Search all CME for Melanomas of skin