Written by epgonline.org - Last updated 29 May 2018
This section encompasses a wide range of skin conditions, comprising a number of separate aetiologies. They fall into this category due to their common inflammatory pathology, although this manifests in very different ways. As one of the primary components of the innate immune system, skin failure has the potential to be catastrophic, as exemplified by toxic epidermal necrolysis or Stevens-Johnson syndrome, although the majority of disease states relating to skin inflammation are less severe. Some of the included disease groups are highlighted below.
Pemphigus is an autoimmune reaction against desmosomes, and can be induced by drugs or as part of a paraneoplastic phenomenon. It results in the formation of blisters, and physiologically behaves like a burn. Pemphigoid disorders are also characterised by large blisters; however, they are distinguished by antibodies against hemidesmosomes, resulting in subepidermal bullae. Lupus erythematosus is a systemic autoimmune condition that can frequently manifest with a variety of cutaneous symptoms.
Psoriasis and its variations are common inflammatory skin conditions; and can cause significant distress due to the chronic nature and cosmetic appearance of the condition. Parapsoriasis is a group of conditions that have a similar appearance to psoriasis, but do not share a common pathology.
Seborrheic dermatitis and eczema are part of this group of diseases. Symptomatically similar, they both result in dry, flaky skin that may be vulnerable to secondary infection. Prurigo nodularis results in itchy nodules, typically on the limbs – while other conditions predominantly relating to pruritis are also included.
Some infective conditions are also located within this section, such as: staphylococcal scalded skin syndrome, infective dermatitis, pityriasis rosea and infantile papular acrodermatitis. There are a significant proportion of inflammatory skin conditions which are idiopathic, such as rosacea, erythema annulare centrifugum and lichen planopilaris.