Latest news articles

Added 5 months ago Drug news

FDA approves Lokelma to treat hyperkalaemia.-AstraZeneca.

The FDA has approved Lokelma (sodium zirconium cyclosilicate), formerly ZS-9, for the treatment of adults with hyperkalaemia, a serious condition...

Added 5 months ago Drug news

FDA accepts sNDA for Veltassa in hyperkalemia.- Relypsa.

Relypsa announced that the FDA has approved a supplemental New Drug Application (sNDA) for Veltassa (patiromer) for oral suspension in...

Added 6 months ago Drug news

EU approves Lokelma to treat hyperkalaemia.- AstraZeneca.

AstraZeneca announced that the European Commission has granted marketing authorisation for Lokelma (formerly ZS-9, sodium zirconium cyclosilicate) for the treatment...

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Learning Zones

An epgonline.org Learning Zone (LZ) is an area of the site dedicated to providing detailed self-directed medical education about a disease, condition or procedure.

Fluid Management

Fluid Management

Are you up-to-date with the latest evidence of effective procedures for fluid management?

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Transplantation

See information on best practice in solid organ transplantation, and expert discussions on related hot topics.

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Guidelines

EASL Clinical Practice Guidelines for the management of patients with decompensated cirrhosis

The following Clinical Practice Guidelines (CPGs) represent the first CPGs on the management of decompensated cirrhosis.

Added 4 months ago

Intravenous fluid therapy in children and young people in hospital

This guideline covers general principles for managing intravenous (IV) fluids for children and young people under 16 years, including assessing...

Added 2 years ago

Clinical practice guideline on diagnosis and treatment of hyponatraemia

The European Society of Intensive Care Medicine (ESICM), the European Society of Endocrinology (ESE) and the European Renal Association–European Dialysis...

Added 4 years ago

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Journal articles

Non-oncotic properties of albumin. A multidisciplinary vision about the implications for critically ill patients.

Effective resuscitation with human albumin solutions is achieved with less fluid than with crystalloid solutions. However, the role of albumin in today's critical care unit is also linked to its multiple pharmacological effects.

Added 7 months ago

Expert Panel Recommendations for the Identification and Management of Hyperkalemia and Role of Patiromer in Patients with Chronic Kidney Disease and Heart Failure.

Virtual panel meetings were conducted among 7 physicians, all of whom are independent experts, including 3 nephrologists, 2 cardiologists, and 2 emergency medicine physicians (the panel).

Added 1 year ago

Goal-directed fluid restriction during brain surgery: a prospective randomized controlled trial.

The value of goal-directed fluid therapy in neurosurgical patients, where brain swelling is a major concern, is unknown.

Added 1 year ago

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Clinical trials

A Two-Part, Single-Blind, Phase 3 Study Evaluating the Efficacy and Safety of Patiromer for the Treatment of Hyperkalemia (OPAL)

The purpose of this study was to evaluate the efficacy and safety of patiromer (investigational drug) in the treatment of hyperkalemia (high serum potassium).

Added 1 year ago

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