Latest news articles
Added 2 months ago Drug news
Phase IIIb DIALIZE trial resultsof Lokelma for hyperkalaemia in patients with end-stage renal disease on haemodialysis
AstraZeneca presented positive results from the Phase IIIb DIALIZE trial which investigated the efficacy and safety of Lokelma (sodium zirconium...
Added 9 months ago Drug news
HARMONIZE Global Phase III trial results for Lokelma presented at ASN Kidney Week.- AstraZeneca.
AstraZeneca presented the results from the HARMONIZE Global Phase III trial, which investigated the safety and efficacy of Lokelma (sodium...
Added 1 year ago Drug news
FDA approves Lokelma to treat hyperkalaemia.-AstraZeneca.
The FDA has approved Lokelma (sodium zirconium cyclosilicate), formerly ZS-9, for the treatment of adults with hyperkalaemia, a serious condition...
Learning Zones
An epgonline.org Learning Zone (LZ) is an area of the site dedicated to providing detailed self-directed medical education about a disease, condition or procedure.
Fluid Management
Are you up-to-date with the latest evidence of effective procedures for fluid management?
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ESICM LIVES Highlights
ESICM LIVES Congress 2018: Bringing you the latest news and insights from the 31st ESICM LIVES Congress, 20–24 October 2018 Paris, France.
Fibrinogen Deficiency in Bleeding
Fibrinogen is important for blood clot formation and breakdown. It is the first coagulant factor to be reduced to critical levels during massive trauma, cardiac surgery and postpartum haemorrhage that involve excessive bleeding. Persistent fibrinogen deficiency can lead to bleeding complications and an increased risk in mortality. This learning zone looks at both congenital and acquired fibrinogen deficiencies including indications and techniques for diagnosis, trigger level for treatment and treatment options.
Hereditary ATTR amyloidosis
Explore the pathophysiology, epidemiology and multi-system symptoms associated with hereditary ATTR amyloidosis, as well as how to achieve an early and accurate diagnosis.
Chronic Lymphocytic Leukaemia (CLL)
Refine your knowledge of chronic lymphocytic leukaemia (CLL) with information on pathophysiology, diagnosis, treatment options and more
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Transplantation
See information on best practice in solid organ transplantation, and expert discussions on related hot topics.
Guidelines
EASL Clinical Practice Guidelines for the management of patients with decompensated cirrhosis
The following Clinical Practice Guidelines (CPGs) represent the first CPGs on the management of decompensated cirrhosis.
Added 1 year ago
Intravenous fluid therapy in children and young people in hospital
This guideline covers general principles for managing intravenous (IV) fluids for children and young people under 16 years, including assessing...
Added 3 years ago
Clinical practice guideline on diagnosis and treatment of hyponatraemia
The European Society of Intensive Care Medicine (ESICM), the European Society of Endocrinology (ESE) and the European Renal Association–European Dialysis...
Added 5 years ago
Journal articles
Non-oncotic properties of albumin. A multidisciplinary vision about the implications for critically ill patients.
Effective resuscitation with human albumin solutions is achieved with less fluid than with crystalloid solutions. However, the role of albumin in today's critical care unit is also linked to its multiple pharmacological effects.
Added 1 year ago
Expert Panel Recommendations for the Identification and Management of Hyperkalemia and Role of Patiromer in Patients with Chronic Kidney Disease and Heart Failure.
Virtual panel meetings were conducted among 7 physicians, all of whom are independent experts, including 3 nephrologists, 2 cardiologists, and 2 emergency medicine physicians (the panel).
Added 1 year ago
Goal-directed fluid restriction during brain surgery: a prospective randomized controlled trial.
The value of goal-directed fluid therapy in neurosurgical patients, where brain swelling is a major concern, is unknown.
Added 1 year ago
Clinical trials
A Two-Part, Single-Blind, Phase 3 Study Evaluating the Efficacy and Safety of Patiromer for the Treatment of Hyperkalemia (OPAL)
The purpose of this study was to evaluate the efficacy and safety of patiromer (investigational drug) in the treatment of hyperkalemia (high serum potassium).
Added 1 year ago