Latest news articles

Added 18 days ago Drug news

Alnylam Pharma provides perspective on positive results from ORION-11 Phase III Study of inclisiran.

Alnylam Pharmaceuticals, Inc. provided perspective on the positive complete results from the ORION-11 Phase III study of inclisiran, an RNAi...

Added 23 days ago Drug news

U.S. District Court invalidates Amgen patent claims targeting PCSK9

Sanofi and Regeneron Pharmaceuticals, Inc. announced that the U.S. District Court for the District of Delaware ruled in their favor...

Added 25 days ago Drug news

Phase III trial of PCSK9si meets all endpoints in CV disease and elevated LDL-cholesterol

The Medicines Company announced positive topline results from the first pivotal Phase III clinical trial evaluating the efficacy, safety, and...

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Learning Zones

An epgonline.org Learning Zone (LZ) is an area of the site dedicated to providing detailed self-directed medical education about a disease, condition or procedure.

Anticoagulation Therapy for Stroke Prevention

Anticoagulation Therapy for Stroke Prevention

Anticoagulation therapy for Stroke Prevention Learning Zone offers a deep-dive into atrial fibrillation causes, consequences, diagnosis and management to help you deliver optimal care and prevent strokes in patients living with this common arrhythmia.

Acute and Advanced Heart Failure

Acute and Advanced Heart Failure

What are the most effective treatments for acute heart failure? Can you define advanced heart failure? Discover here...

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Guidelines

Cardiovascular disease: risk assessment and reduction, including lipid modification

This guideline covers the assessment and care of adults who are at risk of or who have cardiovascular disease (CVD), such as heart disease and stroke. It aims to help healthcare professionals identify people who are at risk of...

Added 5 years ago

2016 ESC/EAS guidelines for the management of dyslipidaemias

The present Guidelines represent an evidence-based consensus, by appraising the current evidence and indentifying remaining knowledge gaps in managing the prevention of dyslipIdaemias...

Added 2 years ago

KDIGO Clinical Practice Guideline for Lipid Management in Chronic Kidney Disease

The 2013 Kidney Disease: Improving Global Outcomes (KDIGO) Clinical Practice Guideline for Lipid Management in Chronic Kidney Disease (CKD) provides guidance on lipid management and treatment for all patients with CKD...

Added 5 years ago

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Journal articles

Association Between Baseline LDL-C Level and Total and Cardiovascular Mortality After LDL-C Lowering: A Systematic Review and Meta-analysis.

Objective: To evaluate whether baseline LDL-C level is associated with total and cardiovascular mortality risk reductions.

Added 1 year ago

Efficacy and Safety of Further Lowering of Low-Density Lipoprotein Cholesterol in Patients Starting With Very Low Levels: A Meta-analysis.

Objective: To evaluate efficacy and safety of further lowering LDL-C levels in patient populations presenting with median LDL-C levels of 1.8 mmol/L (70 mg/dL) or less.

Added 1 year ago

Fenofibrate/simvastatin fixed-dose combination in the treatment of mixed dyslipidemia: safety, efficacy, and place in therapy.

In this review, the effect and safety of an approved combination therapy with simvastatin plus fenofibrate are described, with an analysis of pros and cons resulting from randomized multicenter trials, meta-analyses...

Added 1 year ago

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Clinical trials

A Study in Subjects With Type 2 Diabetes Mellitus With Hypercholesterolemia/Mixed Dyslipidemia

The purpose of this study is to evaluate the effect of 12 weeks of subcutaneous evolocumab taken monthly compared with subcutaneous placebo taken monthly on low density lipoprotein cholesterol (LDL-C) in subjects with...

Added 1 year ago

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