Latest news articles

Added 19 hours ago Drug news

NORTHSTAR-2 and 3 phase III trials of Lentiglobin show efficacy to month 16 in beta-thalassemia.- bluebird bio

bluebird bio announced new data from the Phase III Northstar-2 (HGB-207) and Phase III Northstar-3 (HGB-212) clinical studies of its...

Added 4 days ago Drug news

FDA accepts BLA for luspatercept to treat myelodysplastic syndromes anemia and beta-thalassemia-associated anemia.- Celgene + Acceleron Pharma

Celgene Corporation and Acceleron Pharma Inc. announced that the FDA has accepted Celgene’s Biologics License Application (BLA) for luspatercept, an...

Added 1 month ago Drug news

Pooled cardiovascular safety analyses of the global Phase III programme for roxadustat

AstraZeneca has announced top-line results from the pooled cardiovascular (CV) safety analyses of the global Phase III programme for roxadustat...

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Learning Zones

An epgonline.org Learning Zone (LZ) is an area of the site dedicated to providing detailed self-directed medical education about a disease, condition or procedure.

Oral Anticoagulation Reversal

Oral Anticoagulation Reversal

Experts discuss the use of non-vitamin K oral anticoagulants in the treatment and prevention of stroke, deep vein thrombosis and pulmonary embolism in atrial fibrillation patients.

Chronic Lymphocytic Leukaemia (CLL)

Chronic Lymphocytic Leukaemia (CLL)

Refine your knowledge of chronic lymphocytic leukaemia (CLL) with information on pathophysiology, diagnosis, treatment options and more

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Guidelines

Management of anaemia and iron deficiency in patients with cancer: ESMO Clinical Practice Guidelines

Anaemia and iron deficiency are frequent complications in patients with solid tumours or haematological malignancies, particularly in patients treated with chemotherapeutic agents.

Added 1 year ago

Guidelines for the diagnosis and management of adult aplastic anaemia

This is a comprehensive but pragmatic new guideline and focuses on the accurate diagnosis, delineation of severity types and subsequent management of this rare haematological condition.

Added 3 years ago

The diagnosis and management of primary autoimmune haemolytic anaemia

The objective of this guideline is to provide healthcare professionals with guidance on the management of patients with primary autoimmune haemolytic anaemia (AIHA).

Added 1 year ago

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Journal articles

Causal relationship between hypoalbuminemia and acute kidney injury.

Our meta-analysis published in 2010 provided evidence that low levels of serum albumin (hypoalbuminemia) are a significant independent predictor of acute kidney injury (AKI) and death following AKI.

Added 1 year ago

Could testosterone therapy in hypogonadal men ameliorate anemia, a cardiovascular risk factor? An observational, 54-week cumulative registry study.

In this study we investigated if testosterone undecanoate attenuates anemia and the risk of cardiovascular disease in patients with hypogonadism.

Added 1 year ago

Treatment of Atypical Hemolytic-Uremic Syndrome in the Era of Eculizumab.

Hemolytic-uremic syndrome (HUS) is the triad of microangiopathic hemolytic anemia (MAHA), thrombocytopenia, and acute kidney injury (AKI); the main cause of multi-organ failure is related to thrombotic microangiopathy (TMA).

Added 2 years ago

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Clinical trials

An Efficacy and Safety Study of Luspatercept (ACE-536) Versus Placebo in Adults Who Require Regular Red Blood Cell Transfusions Due to Beta (β) Thalassemia (BELIEVE)

This is a Phase 3, double-blind, randomized, placebo-controlled, multicenter study to determine the efficacy and safety of luspatercept (ACE-536) plus Best supportive care (BSC) versus placebo plus BSC in...

Added 11 months ago

A Study Evaluating the Efficacy and Safety of LentiGlobin BB305 Drug Product in Beta-Thalassemia Major and Sickle Cell Disease

This is a Phase 1/2, open label, safety, and efficacy study of the administration of LentiGlobin BB305 Drug Product to subjects with either beta-thalassemia major or severe sickle cell disease (SCD).

Added 6 years ago

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CME

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