Data from multiple sources - Curated by Marshall Pearce - Last updated 06 June 2017
Cystic fibrosis (CF) is an autosomal recessive, life-limiting, genetically inherited disease. It is a multi-system disorder and results from one of several identified...
Added 14 days ago Drug news
Vertex Pharmaceuticals announced that the New England Journal of Medicine (NEJM) published two articles with results from two Phase III...
Added 5 months ago Drug news
Kalydeco is FDA approved for use in cystic fibrosis patients ages 2 and older who have one of 23 residual function mutations in the CFTR gene.- Vertex Pharma
Vertex Pharmaceuticals Incorporated announced that the FDA has approved Kalydeco (ivacaftor) for use in people with cystic fibrosis (CF) ages...
Added 7 months ago Drug news
Two Phase III studies reported of tezacaftor (VX-661) / ivacaftor combination of cystic fibrosis transmembrane conductance regulator (CFTR) gene affected patients.-Vertex
Vertex Pharmaceuticals Incorporated announced results from two Phase III studies of the tezacaftor (VX-661) / ivacaftor combination treatment that showed...
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Specialised CF care has led to a dramatic improvement in survival in CF: in the last four decades, well above...
Added 3 years ago
This review summarizes state-of-the art culture methods and makes recommendations for addition of non-culture based methods in the diagnostic laboratory.
Added 4 years ago
Inert gas washout tests, performed using the single- or multiple-breath washout technique, were first described over 60 years ago. As...
Added 5 years ago
Background: Cystic fibrosis is an autosomal recessive disease caused by mutations in the CFTR gene that lead to progressive respiratory decline. Some mutant CFTR proteins show residual function and...
Added 11 days ago
Introduction: Lumacaftor-ivacaftor is indicated for treatment of cystic fibrosis (CF) in patients homozygous for the Phe-508del cystic fibrosis transmembrane conductance regulator (CFTR) gene mutations.
Added 29 days ago
Lumacaftor/ivacaftor, a novel agent for the treatment of cystic fibrosis patients who are homozygous for the F580del CFTR mutation.
Introduction: Cystic Fibrosis (CF) is an autosomal recessive disease affecting up to 90,000 people worldwide. Approximately 73% of patients are homozygous for the F508del cystic fibrosis transmembrane conductance regulator...
Added 29 days ago
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