Cystic fibrosis (CF) is an autosomal recessive, life-limiting, genetically inherited disease. It is a multi-system disorder and results from one of several identified...
Added 1 day ago Drug news
Vertex Pharmaceuticals Incorporated announced the FDA approved Kalydeco (ivacaftor) to include use in children with cystic fibrosis (CF) ages 12...
Added 9 days ago Drug news
FDA approves Orkambi to include use in children ages 2 through 5 years with cystic fibrosis who have two copies of the F508del-CFTR mutation.- Vertex Pharma.
Vertex Pharmaceuticals Incorporated announced the FDA has approved Orkambi (lumacaftor/ivacaftor) to include use in children ages 2 through 5 years...
Added 19 days ago Drug news
CHMP recommends Symkevi + Kalydeco to treat children with cystic fibrosis aged 12 and older.- Vertex.
Vertex Pharmaceuticals (Europe) Limited, announced that the European Medicines Agency’s Committee for Medicinal Products for Human Use (CHMP) adopted a...
An epgonline.org Learning Zone (LZ) is an area of the site dedicated to providing detailed self-directed medical education about a disease, condition or procedure.
View disease awareness information, treatment options and European Cystic Fibrosis Society best practice guidelines.
See information on best practice in solid organ transplantation, and expert discussions on related hot topics.
The Inflammatory Bowel Disease (IBD) Knowledge Centre contains key information relating to the epidemiology and pathophysiology of Crohn’s disease and ulcerative colitis, highlighting prevalence, impact and unmet needs and the underlying inflammatory processes that drive IBD, considering some of the key inflammatory pathways.
This guideline covers diagnosing and managing cystic fibrosis. It specifies how to monitor the condition and manage the symptoms to improve quality of life.
Added 2 months ago
Specialised CF care has led to a dramatic improvement in survival in CF: in the last four decades, well above what was seen in the general population over the same period.
Added 4 years ago
Palliative care is an approach that improves quality of life for patients and their families facing problems associated with a life-threatening illness. Care planning is particularly important in CF...
Added 7 years ago
Ivacaftor treatment of cystic fibrosis in children aged 12 to <24 months and with a CFTR gating mutation (ARRIVAL): a phase 3 single-arm study.
Background: Ivacaftor is generally safe and effective in patients aged 2 years and older who have cystic fibrosis and specific CFTR mutations. We assessed its use in children aged 12 to <24 months.
Added 1 month ago
Ivacaftor restores CFTR-dependent sweat gland fluid secretion in cystic fibrosis subjects with S945L alleles.
Background: To determine in vivo effects of CFTR modulators on mutation S945L.
Added 6 months ago
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