Latest news articles

Added 1 month ago Drug news

Itacitinib fails to meet primary endpoint in phase III GRAVITAS-301 study to treat graft-versus-host disease.- Incyte Corpn.

Incyte Corporation announced that the pivotal Phase III GRAVITAS-301 study evaluating itacitinib in combination with corticosteroids in patients with treatment-naïve...

Added 2 months ago Drug news

BMS announces FDA breakthrough therapy designation for Orencia to help prevent acute graft-versus-host disease, a potentially life-threatening complication after stem cell transplant.- BMS

Bristol-Myers Squibb Company announced that the FDA has granted Breakthrough Therapy Designation for Orencia (abatacept) for the prevention of moderate...

Added 3 months ago Drug news

Uvadex is approved in Australia for use with the Therakos Cellex Photopheresis System for treatment of chronic graft versus host disease (cGvHD) and skin manifestations of cutaneous T-cell lymphoma in adults. Mallinckrodt

Mallinckrodt Plc announced that Uvadex (methoxsalen) has received regulatory approval in Australia by the Therapeutic Goods Administration (TGA) for extracorporeal...

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Learning Zones

An Learning Zone (LZ) is an area of the site dedicated to providing detailed self-directed medical education about a disease, condition or procedure.



See information on best practice in solid organ transplantation, and expert discussions on related hot topics.

Fibrinogen Deficiency in Bleeding

Fibrinogen Deficiency in Bleeding

Fibrinogen is important for blood clot formation and breakdown. It is the first coagulant factor to be reduced to critical levels during massive trauma, cardiac surgery and postpartum haemorrhage that involve excessive bleeding. Persistent fibrinogen deficiency can lead to bleeding complications and an increased risk in mortality. This learning zone looks at both congenital and acquired fibrinogen deficiencies including indications and techniques for diagnosis, trigger level for treatment and treatment options.

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EASL Clinical Practice Guidelines: Liver transplantation

This Clinical Practice Guideline (CPG) has been developed to assist physicians and other healthcare providers during the evaluation process of candidates for LT and to help them in the correct management of patients after LT.

Added 4 years ago

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Journal articles

Faecal microbiota transplantation: a regulatory hurdle?

During faecal microbiota transplantation, stool from a healthy donor is transplanted to treat a variety of dysbiosis-associated gut diseases. Competent authorities are faced with the challenge to provide adequate regulation.

Added 9 months ago

Steatosis in Liver Transplantation: Current Limitations and Future Strategies.

This review focuses on the current and potential future treatment of NASH and the clinical practice in fatty liver transplantation, highlights its limitations and optimal allocation, and summarizes the advances of experimental...

Added 10 months ago

Bone marrow versus peripheral blood as a graft source for haploidentical donor transplantation in adults using post-transplant cyclophosphamide-A systematic review and meta-analysis.

Background: Peripheral-blood (PB) and bone marrow (BM) are both widely used in hematopoietic stem cell transplantation (HSCT). However, it is unclear whether PB or BM produces a more satisfactory outcome in haploidentical HSCT...

Added 10 months ago

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Clinical trials

Letermovir (MK-8228) Versus Placebo in the Prevention of Clinically-Significant Cytomegalovirus (CMV) Infection in Adult, CMV-Seropositive Allogeneic Hematopoietic Stem Cell Transplant Recipients (MK-8228-001)

The study evaluated the efficacy and safety of letermovir (MK-8228) for the prevention of clinically-significant CMV infection in adult, CMV-seropositive recipients of allogeneic hematopoietic stem cell transplant (HSCT).

Added 2 years ago

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Jonathan Macdonald

ECCMID 2018 ‒ Antibiotic resistance: an immediate and growing threat

This year’s ECCMID is hosting a large number of sessions discussing antibiotic resistance, an immediate and pressing issue that has been described as ‘one of the biggest threats to global health, food security, and development today'.


Starting patients on anticoagulants in secondary care: how to do it

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