Added 2 days ago Drug news
Genentech now reports that earlier this year, Genentech initiated IMbrave150 (NCT03434379), an open-label, multicenter, randomized Phase III study investigating the...
Added 7 days ago Drug news
NEJM publishes results of CELESTIAL trial of Cabometyx in patients with previously treated advanced hepatocellular carcinoma.- Ipsen + Exelixis.
Ipsen announced that The New England Journal of Medicine (NEJM) published results from the CELESTIAL phase III pivotal trial of...
Added 9 days ago Drug news
The FDA has accepted and granted priority review for a new supplemental Biologics License Application (sBLA) seeking approval for Keytruda...
An epgonline.org Learning Zone (LZ) is an area of the site dedicated to providing detailed self-directed medical education about a disease, condition or procedure.
See information on best practice in solid organ transplantation, and expert discussions on related hot topics.
Experts discuss the use of non-vitamin K oral anticoagulants in the treatment and prevention of stroke, deep vein thrombosis and pulmonary embolism in atrial fibrillation patients.
View disease awareness information, treatment options and European Cystic Fibrosis Society best practice guidelines.
The Inflammatory Bowel Disease (IBD) Knowledge Centre contains key information relating to the epidemiology and pathophysiology of Crohn’s disease and ulcerative colitis, highlighting prevalence, impact and unmet needs and the underlying inflammatory processes that drive IBD, considering some of the key inflammatory pathways.
This learning zone offers a short overview of the challenges faced by both healthcare professionals and patient when communicating end-stage or metastatic cancer.
The following Clinical Practice Guidelines will give up-to-date advice for the clinical management of patients with hepatocellular carcinoma, as well as providing an in-depth review of all the relevant data leading to the conclusions herein.
Added 1 month ago
These guidelines focus on diagnosis and pathology/molecular biology, staging and risk assessment and management of biliary cancer including follow-up and long-term implications.
Added 7 years ago
This Clinical Practice Guideline (CPG) has been developed to assist physicians and other healthcare providers during the evaluation process of candidates for LT and to help them in the correct management of patients after LT.
Added 2 years ago
Cabozantinib inhibits tyrosine kinases, including vascular endothelial growth factor receptors 1, 2, and 3, MET, and AXL, which are implicated in the progression of hepatocellular carcinoma and the development of resistance...
Added 5 days ago
The role of liver resection in the management of intermediate and advanced stage hepatocellular carcinoma. A systematic review.
Background: The ideal management for patients with intermediate and advanced stage hepatocellular carcinoma (HCC) is controversial. The main purpose of this systematic review is to examine the role of liver resection...
Added 6 months ago
Interaction of margin status and tumour burden determines survival after resection of colorectal liver metastases: A retrospective cohort study.
Purpose: We sought to determine the impact of surgical margin status on overall survival (OS) and recurrence pattern stratified by tumor burden.
Added 6 months ago
The primary objective is to prove non-inferiority of thermal ablation compared to hepatic resection in patients with at least one resectable and ablatable colorectal liver metastases (≤3cm) and no extrahepatic disease.
Added 8 months ago
Study of Pembrolizumab (MK-3475) or Placebo Given With Best Supportive Care in Asian Participants With Previously Treated Advanced Hepatocellular Carcinoma (MK-3475-394/KEYNOTE-394)
The purpose of this study is to determine the efficacy and safety of pembrolizumab or placebo given with best supportive care (BSC) in Asian participants with previously systemically treated advanced hepatocellular carcinoma (HCC).
Added 5 days ago
This study involves a course of radiation to up to 5 tumors in the participant's liver followed by systemic therapy (Treatment using substances that travel through the bloodstream, reaching and affecting cells all over the body).
Added 1 year ago
Alex studied Biological Sciences at university before joining EPG Health in January 2017, where he works as a digital content manager and editor.
In his spare time, Alex enjoys relaxing with a cool pint in the company of good friends.
A number of studies from the speakers at this year's ILC Basic Science Seminar are discussed here, focusing on targetable pathways in liver disease, covering pathway identification, potential drug targets and their clinical application.