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Added 1 month ago Drug news

Pooled cardiovascular safety analyses of the global Phase III programme for roxadustat

AstraZeneca has announced top-line results from the pooled cardiovascular (CV) safety analyses of the global Phase III programme for roxadustat...

Added 5 months ago Drug news

Positive results from three phase III studies of roxadustat for anemia in patients with chronic kidney disease. FibroGen + AstraZeneca

FibroGen, Inc. announced that roxadustat, an inhibitor of hypoxia-inducible-factor (HIF) prolyl hydroxylase activity (HIF-PHI), met all primary efficacy endpoints in...

Added 6 months ago Drug news

Phase III OLYMPUS and ROCKIES trials for roxadustat each met their primary efficacy endpoints for the treatment of patients with anaemia in chronic kidney disease . AstraZeneca + FibroGen

AstraZeneca announced that the Phase III OLYMPUS and ROCKIES trials for roxadustat each met their primary efficacy endpoints for the...

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Learning Zones

An epgonline.org Learning Zone (LZ) is an area of the site dedicated to providing detailed self-directed medical education about a disease, condition or procedure.

Fibrinogen Deficiency in Bleeding

Fibrinogen Deficiency in Bleeding

Fibrinogen is important for blood clot formation and breakdown. It is the first coagulant factor to be reduced to critical levels during massive trauma, cardiac surgery and postpartum haemorrhage that involve excessive bleeding. Persistent fibrinogen deficiency can lead to bleeding complications and an increased risk in mortality. This learning zone looks at both congenital and acquired fibrinogen deficiencies including indications and techniques for diagnosis, trigger level for treatment and treatment options.

Transplantation

Transplantation

See information on best practice in solid organ transplantation, and expert discussions on related hot topics.

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Journal articles

Benzodiazepine-associated delirium in critically ill adults.

The association between benzodiazepine use and delirium risk in the ICU remains unclear.

Added 1 year ago

Sedation depth and long-term mortality in mechanically ventilated critically ill adults: a prospective longitudinal multicentre cohort study.

To ascertain the relationship among early (first 48 h) deep sedation, time to extubation, delirium and long-term mortality.

Added 1 year ago

Early intensive care sedation predicts long-term mortality in ventilated critically ill patients.

Choice and intensity of early (first 48 h) sedation may affect short- and long-term outcome.

Added 1 year ago

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CME

Heavy menstrual bleeding in primary care: putting NICE guidelines into practice

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