Latest news articles

Added 13 days ago Drug news

ENTRUST-AF PCI study of Lixiana shows non-inferiority in atrial fibrillation, and is published in The Lancet

Daiichi Sankyo announced results from ENTRUST-AF PCI, the first large randomised study to evaluate the efficacy and safety of once-daily...

Added 15 days ago Drug news

One-year outcomes study of Lixiana shows efficacy in atrial fibrillation.- Daiichi Sankyo

Daiichi Sankyo announced one-year outcomes results from a study of 24,962 patients with non-valvular atrial fibrillation (NVAF) treated with Lixiana...

Added 16 days ago Drug news

NAXOS real-world study of Eliquis shows reduced bleeding and stroke in non-valvular atrial fibrillation.- BMS/Pfizer

Bristol-Myers Squibb/Pfizer announced findings from NAXOS, the largest real-world data analysis on oral anticoagulant (OAC) effectiveness and safety in Europe...

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Learning Zones

An epgonline.org Learning Zone (LZ) is an area of the site dedicated to providing detailed self-directed medical education about a disease, condition or procedure.

Fibrinogen Deficiency in Bleeding

Fibrinogen Deficiency in Bleeding

Fibrinogen is important for blood clot formation and breakdown. It is the first coagulant factor to be reduced to critical levels during massive trauma, cardiac surgery and postpartum haemorrhage that involve excessive bleeding. Persistent fibrinogen deficiency can lead to bleeding complications and an increased risk in mortality. This learning zone looks at both congenital and acquired fibrinogen deficiencies including indications and techniques for diagnosis, trigger level for treatment and treatment options.

Transplantation

Transplantation

See information on best practice in solid organ transplantation, and expert discussions on related hot topics.

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Guidelines

2019 AHA/ACC/HRS Focused Update of the 2014 AHA/ACC/HRS Guideline for the Management of Patients With Atrial Fibrillation: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart R

The scope of this focused update of the 2014 AF Guideline includes revisions to the section on anticoagulation (because of the approval of new medications and thromboembolism protection devices), revisions to the section...

Added 1 month ago

Stroke and transient ischaemic attack in over 16s: diagnosis and initial management

This guideline covers interventions in the acute stage of a stroke or transient ischaemic attack (TIA). It offers the best clinical advice on the diagnosis and acute management of stroke and TIA in the 48 hours after onset of symptoms.

Added 1 month ago

2018 ESC/EACTS Guidelines on myocardial revascularization

These Guidelines represent the third time that the ESC and EACTS have brought together cardiologists and cardiac surgeons in a joint Task Force to review the ever-increasing body of evidence, with the mission of drafting balanced...

Added 4 years ago

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Journal articles

Reversal of oral anticoagulation in patients with acute intracerebral hemorrhage.

In light of an aging population with increased cardiovascular comorbidity, the use of oral anticoagulation (OAC) is steadily expanding. A variety of pharmacological alternatives to vitamin K antagonists (VKA) have emerged...

Added 13 days ago

Reversal agents for direct oral anticoagulants: considerations for hospital physicians and intensivists.

Direct oral anticoagulants (DOACs) include dabigatran etexilate, a direct thrombin inhibitor, and specific inhibitors of activated coagulation factor X (FXa; e.g. apixaban, betrixaban, edoxaban, rivaroxaban).

Added 13 days ago

Andexanet alfa for the reversal of factor Xa inhibitors.

Introduction: Andexanet alfa is a recombinant modified factor Xa protein that has been developed to reverse factor Xa inhibitors. Since May 2018, the FDA has approved its utilization in patients treated with apixaban and...

Added 13 days ago

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Clinical trials

Trial of Andexanet in ICH Patients Receiving an Oral FXa Inhibitor

Randomized, controlled clinical trial evaluating the efficacy and safety of andexanet versus usual standard of care in patients with intracranial hemorrhage anticoagulated with a direct oral anticoagulant

Added 3 months ago

A Study in Patients With Acute Major Bleeding to Evaluate the Ability of Andexanet Alfa to Reverse the Anticoagulation Effect of Direct and Indirect Oral Anticoagulants (Extension Study)

The purpose of this study is to evaluate the hemostatic efficacy of andexanet alfa in patients receiving a factor Xa inhibitor who are experiencing an acute major bleed. The safety of andexanet will also be studied.

Added 5 months ago

Clinical Mismatch in the Triage of Wake Up and Late Presenting Strokes Undergoing Neurointervention With Trevo (DAWN)

The purpose of the study is to evaluate the hypothesis that Trevo thrombectomy plus medical management leads to superior clinical outcomes at 90 days as compared to medical management alone in appropriately selected subjects...

Added 1 year ago

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CME

Stroke: clinical review

Accrediting body
MIMS Learning - Monthly Index of Medical Specialities
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