Latest news articles

Added 4 days ago Drug news

Phase IIIb ELIMINATE-AF study of Lixiana shows safety and efficacy in bleeding events

Daiichi Sankyo announced results from phase IIIb ELIMINATE-AF, a prospective, randomised, open label, blinded endpoint evaluation (PROBE) design study assessing...

Added 4 days ago Drug news

Real-world study of Xarelto finds efficacy and cost saving in atrial fibrillation

The Janssen Pharmaceutical Companies of Johnson & Johnson announced results of a new real-world study, which found newly diagnosed patients...

Added 4 days ago Drug news

EMIT-AF/VTE study of Lixiana finds low bleeding rates in patients at risk of stroke and VTE

Daiichi Sankyo announced the results from EMIT-AF/VTE, a prospective, non-interventional study of oral, once-daily Lixiana (edoxaban) in the peri-procedural management...

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Learning Zones

An epgonline.org Learning Zone (LZ) is an area of the site dedicated to providing detailed self-directed medical education about a disease, condition or procedure.

Migraine Knowledge Centre

Migraine Knowledge Centre

The Migraine Knowledge Centre features latest research on the prevalence and impact of migraine, the proposed neurological basis of the condition (and how this is being translated into new and exciting drug therapies), as well as current patient care strategies collated from headache organisations worldwide.

Oral Anticoagulation Reversal

Oral Anticoagulation Reversal

Experts discuss the use of non-vitamin K oral anticoagulants in the treatment and prevention of stroke, deep vein thrombosis and pulmonary embolism in atrial fibrillation patients.

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Guidelines

European Stroke Organisation (ESO) guidelines on glycaemia management in acute stroke

Hyperglycaemia is a frequent complication in acute stroke that has been shown to be independently associated with larger infarct size, haematoma growth, poor clinical outcome and mortality.

Added 9 months ago

European Academy of Neurology and European Stroke Organization consensus statement and practical guidance for pre-hospital management of stroke

The objective is to recommend evidence-based practices for the management of patients with suspected stroke in the pre-hospital setting.

Added 9 months ago

Management of Atherosclerotic Carotid and Vertebral Artery Disease: 2017 Clinical Practice Guidelines of the European Society for Vascular Surgery (ESVS)

The European Society for Vascular Surgery (ESVS) has prepared guidelines for treating patients with atherosclerotic carotid and vertebral artery (VA) disease.

Added 1 year ago

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Journal articles

Reversal Strategies for Intracranial Hemorrhage Related to Direct Oral Anticoagulant Medications.

Direct oral anticoagulants (DOACs) are a new class of anticoagulants that directly inhibit either thrombin or factor Xa in the coagulation cascade. They are being increasingly used instead of warfarin or other vitamin K antagonists (VKAs).

Added 3 days ago

Full Study Report of Andexanet Alfa for Bleeding Associated with Factor Xa Inhibitors.

Background: Andexanet alfa is a modified recombinant inactive form of human factor Xa developed for reversal of factor Xa inhibitors.

Added 3 days ago

Acute reversal of dabigatran with Idarucizumab for intravenous thrombolysis as acute stroke treatment.

Intravenous thrombolysis with recombinant tissue plasminogen activator (rt-PA) for acute ischemic stroke (AIS) is contraindicated in patient taking either Factor Xa inhibitors or direct thrombin inhibitors.

Added 3 days ago

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Clinical trials

A Study in Patients With Acute Major Bleeding to Evaluate the Ability of Andexanet Alfa to Reverse the Anticoagulation Effect of Direct and Indirect Oral Anticoagulants (Extension Study)

The purpose of this study is to evaluate the hemostatic efficacy of andexanet alfa in patients receiving a factor Xa inhibitor who are experiencing an acute major bleed. The safety of andexanet will also be studied.

Added 3 days ago

Clinical Mismatch in the Triage of Wake Up and Late Presenting Strokes Undergoing Neurointervention With Trevo (DAWN)

The purpose of the study is to evaluate the hypothesis that Trevo thrombectomy plus medical management leads to superior clinical outcomes at 90 days as compared to medical management alone in appropriately selected subjects...

Added 1 year ago

Rivaroxaban for the Prevention of Major Cardiovascular Events in Coronary or Peripheral Artery Disease (COMPASS)

The primary purpose of this study is to evaluate whether treatment with rivaroxaban and aspirin or rivaroxaban alone is better than aspirin alone in prevention of heart attacks, stroke or cardiovascular death...

Added 7 years ago

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CME

Stroke: clinical review

Accrediting body
MIMS Learning - Monthly Index of Medical Specialities
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