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Added 38 seconds ago Drug news

Interim data for LentiGlobin gene therapy to eliminate or reduce chronic blood transfusions in patients with transfusion-dependent beta-thalassemia is published in NEJM.- bluebird bio,Inc.

bluebird bio, Inc. announced interim data published in the New England Journal of Medicine (NEJM) from two separate two-year clinical...

Added 38 seconds ago Drug news

NICE gives final opinion approving use of RoActemra in giant cell arteritis.- Roche/Chugai.

In final guidance, the National Institute of Health and Care Excellence has given its support for the use of RoActemra...

Added 42 seconds ago Drug news

FDA approves Tagrisso for first line treatment of NSCLC with epidermal growth factor receptor (EGFR) mutations.- AstraZeneca.

AstraZeneca announced that the FDA has approved Tagrisso (osimertinib) for the 1st-line treatment of patients with metastatic non-small cell lung...

Looking to the horizon - Breakthrough drugs and treatments

Marshall Pearce

Antibody-drug conjugates (ADCs)

Posted 1 year ago

Over the past couple of decades, there have been advances in a class of drugs which for a long time was purely theoretical: antibody-drug conjugates (ADCs). The concept underlying ADCs is elegant – what if it were possible to ‘target’ particular groups of cells with a cytotoxic agent, rather than exposing every cell of the body to it?

Marshall Pearce

Cancer immunotherapies

Posted 11 months ago

It was the winner of the 1908 Nobel prize for medicine, Paul Ehrlich, who is first credited with discussing the concept of a “magic bullet”, able to target specific cells without damaging healthy tissue. With the advent of immunotherapy, as well as antibody-drug conjugates, we are beginning to realise this vision.

Marshall Pearce

How close are we to a disease-modifying treatment for Alzheimer’s?

Posted 4 months ago

Alzheimer’s disease is a snowballing problem, one that is currently without a convincing solution. The progressive decline in cognitive function seen in patients with Alzheimer’s disease is associated strongly with plaques formed of amyloid beta in the brain, creating neurofibrillary tangles and leading to neuronal destruction. While some treatments improve cognition in the short-term, current therapeutic options are unable to modify or slow the disease process.