Venous thromboembolism (VTE) is a major complication following solid organ transplantation with an incidence that ranges from 2% to 34%, depending on the type of surgery performed (see table below) (Sáez-Giménez et al., 2015).
Table 1: Incidence of VTE in different populations (Sáez-Giménez et al., 2015).
Risk factors for VTE in solid organ transplant recipients include inherited thrombophilia, impaired fibrinolysis due to corticosteroids, endothelial damage due to CMV infection, and specific surgical factors. Whether calcineurin inhibitors have a clinical procoagulant effect, which can be observed in vitro is unclear at present (Sáez-Giménez et al., 2015).
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