Failure/Complication Rates and Comorbidities

Post-operative complications of solid organ transplantation can be categorised into three groups:

  • those arising from recipient comorbidities such as diabetes, obesity, renal insufficiency and cardiovascular disease
  • secondary complications arising from waiting for an allograft, e.g. musculoskeletal deconditioning, malnutrition, coagulopathy, reduced cardiopulmonary function, immune compromise
  • complications consequent to surgery (Diaz and O'Connor, 2011).

Ten-year graft survival following solid organ transplantation is shown in the figure below (Collaborative Transplant Study (CTS), 2016). Although short-term survival is excellent (>90%), long-term survival is poor reflecting recurrence of disease, development of chronic rejection or complications related to the need for long-term immunosuppression.

Graft survival following solid organ transplantation (Collaborative Transplant Study (CTS), 2016).

Figure 5: Graft survival following solid organ transplantation (Collaborative Transplant Study (CTS), 2016).