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Oral Anticoagulation Reversal

Oral Anticoagulation Reversal Learning Zone

Declaration of sponsorship CSL Behring

Publications

Declaration of sponsorship CSL Behring

Read time: 90 mins

Last updated:1st Feb 2022

Published:26th Oct 2020

The Publications Digest section of the Learning Zone is dedicated to providing analysis and commentary of relevant published literature. Recent publications will be reviewed and distilled into key learning points for your convenience, sorted by year of publication.

Digests have covered a comprehensive range of topics around oral anticoagulation and its reversal, such as the use of 3- and 4-factor prothrombin complex concentrate, thromboembolic events after vitamin K antagonist reversal, emergency reversal of vitamin K antagonists, managing target-specific oral anticoagulant associated bleeding, and more.

Recently added

Oral anticoagulant reversal agent use in paediatric patients: a survey

15 mins

Updates in Anticoagulation Therapy Monitoring

15 mins

Ciraparantag, an anticoagulant reversal drug: mechanism of action, pharmacokinetics, and reversal of anticoagulants

10 mins

Managing bleeds related to oral factor Xa inhibitors with andexanet alfa or replacement agents

15 mins

Anticoagulation reversal for intracranial haemorrhage in the era of the direct oral anticoagulants

10 mins

A review of guidelines on anticoagulation reversal across different clinical scenarios – Is there a general consensus?

10 mins

Reversal of direct oral anticoagulants

10 mins

3F-PCC in paediatric cardiac surgery

10 mins

Oral anticoagulant use in patients with AF

10 mins

Lung transplant anticoagulation strategies

10 mins

Initiation of a fixed‐dose 4F-PCC protocol

10 mins

aPCC versus 4F-PCC for warfarin reversal

10 mins

Evaluating high-dose 4F-PCC for WICH reversal

10 mins

Comparing 3-PCC and 4-PCC warfarin reversal

20 mins

Evaluating fixed-dose 4F-PCC for VKA reversal

15 mins

Direct oral anticoagulants: a review on the current role and scope of reversal agents

15 mins

Efficacy and safety of prothrombin complex concentrate in patients treated with rivaroxaban or apixaban compared to warfarin presenting with major bleeding

3 mins

Evaluation of the use of low-dose 4-factor prothrombin complex concentrate in the reversal of direct oral anticoagulants in bleeding patients

3 mins

Prothrombin complex concentrate reversal of coagulopathy in emergency general surgery patients

3 mins

Four factor prothrombin complex concentrate for warfarin reversal in patients with left ventricular assist devices

4 mins

Safety of 4-factor prothrombin complex concentrate (4F-PCC) for emergent reversal of factor Xa inhibitors

3 mins

Intraoperative administration of 4-factor prothrombin complex concentrate reduces blood requirements in cardiac transplantation

3 mins

Direct oral anticoagulants (DOAC) - Management of emergency situations. Rationale and design of the RADOA-Registry

5 mins

Coagulation management during liver transplantation: use of fibrinogen concentrate, recombinant activated Factor VII, prothrombin complex concentrate, and antifibrinolytics

4 mins

A retrospective propensity score-matched early thromboembolic event analysis of prothrombin complex concentrate vs. fresh frozen plasma for warfarin reversal prior to emergency neurosurgical procedure

3 mins

The effect of time to international normalized ratio reversal on intracranial hemorrhage evolution in patients with traumatic brain injury

3 mins

Three-factor versus four-factor prothrombin complex concentrate for warfarin reversal - a critical appraisal of the evidence

1 mins

Reversal of dabigatran-associated major bleeding with activated prothrombin concentrate: A prospective cohort study

2 mins

Comparison of 3-factor versus 4-factor prothrombin complex concentrate with regard to warfarin reversal, blood product use, and costs

2 mins

Anticoagulation-associated intracranial haemorrhage in the era of reversal agents

3 mins

Management of severe bleeding in patients treated with direct oral anticoagulants: an observational registry analysis

2 mins

Medical treatment for spontaneous anticoagulation-related intracerebral hemorrhage in the Netherlands

2 mins

Role of prothrombin complex concentrate (PCC) in acute intracerebral hemorrhage with positive CTA spot sign: an institutional experience at a regional and state designated stroke center

2 mins

Added 2016

Thromboembolic events after vitamin K antagonist reversal with 4-factor prothrombin complex concentrate: exploratory analyses of two randomized, plasma-controlled studies

3 mins

Assessing the efficacy of prothrombin complex concentrate in multiply injured patients with high-energy pelvic and extremity fractures

2 mins

Prothrombin complex concentrates versus fresh frozen plasma for warfarin reversal: A systematic review and meta-analysis

2 mins

Fresh frozen plasma versus prothrombin complex concentrate in patients with intracranial haemorrhage related to vitamin K antagonists (INCH): a randomised trial

2 mins

Is there a difference in efficacy, safety, and cost-effectiveness between 3-factor and 4-factor prothrombin complex concentrates among trauma patients on oral anticoagulants?

2 mins

Treatment with prothrombin complex concentrate to enable emergency lumbar puncture in patients receiving vitamin K antagonists

2 mins

Emergency reversal of vitamin K antagonists: addressing all the factors

1 mins

Reversibility of apixaban anticoagulation with a four-factor prothrombin complex concentrate in healthy volunteers

1 mins

Added 2015

Use of prothrombin complex concentrate in warfarin anticoagulation reversal in the emergency department: a quality improvement study of administration delays

3 mins

Budget impact analysis of warfarin reversal therapies among hip fracture patients in Finland

3 mins

Cutting delays in reversing anticoagulation after intracerebral haemorrhage: three key changes at a UK comprehensive stroke centre

2 mins

Managing target-specific oral anticoagulant associated bleeding, including an update on pharmacological reversal agents

1 mins

Increased risk of volume overload with plasma compared with four-factor prothrombin complex concentrate for urgent vitamin K antagonist reversal

1 mins

Comparison of novel oral anticoagulants versus vitamin K antagonists in patients with chronic kidney disease

1 mins

Updates in the perioperative and emergency management of non-vitamin K antagonist oral anticoagulants

1 mins

Prothrombin complex concentrate versus fresh-frozen plasma for reversal of coagulopathy of trauma: is there a difference?

2 mins

Prothrombin complex concentrate versus fresh-frozen plasma for reversal of coagulopathy of trauma: is there a difference?

2 mins

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