Hereditary tyrosinemia type 1 (HT-1) Nitisinone is indicated for the treatment of adult and paediatric (in any age range) patients with confirmed diagnosis of hereditary tyrosinemia type 1 (HT-1) in combination with dietary restriction of tyrosine and phenylalanine. Alkaptonuria (AKU) Nitisinone is indicated for the treatment of adult patients with alkaptonuria (AKU).