i-STAT TnI-Nx, a point-of-care diagnostic test success reported in JAMA Cardiology.- Abbott

For someone experiencing cardiac symptoms in the emergency room, every minute matters as physicians determine whether someone is having a heart attack. New data, published online in JAMA Cardiology, found a new blood test under development that is done right at the patient's side in as little as 15 minutes could identify nearly three-fifths (56.7 percent) of people at low-risk of experiencing a heart attack, similar to the results of a High Sensitive Troponin-I blood test done in the laboratory setting.

Researchers in New Zealand evaluated 354 adults 18 years and older who entered an emergency department with symptoms of acute coronary syndrome, such as a heart attack. The patients' cardiac troponin levels, which have become the standard for aiding doctors in checking for a heart attack, were measured using two Abbott blood tests: the ARCHITECT High Sensitive Troponin-I (hsTnI) and the i-STAT TnI-Nx, a point-of-care diagnostic test under development. The study found: Similar levels of accuracy between the two tests (area under the curve: 0.975 and 0.970 for the i-STAT TnI-Nx and hsTnI tests respectively). Similar abilities to rule out a heart attack using the Emergency Department Assessment of Chest Pain Score: 56.7 percent of patients were identified as low risk using i-STAT TnI-Nx, compared to 43.5 percent of patients using hsTnI test.

See- "Validity of a Novel Point-of-Care Troponin Assay for Single-Test Rule-Out of Acute Myocardial Infarction"- John W. Pickering, PhD; Joanna M. Young, PhD; Peter M. George, BSc, MBBS; et al JAMA Cardiol. Published online October 17, 2018. doi:10.1001/jamacardio.2018.3368.

Comment: ARCHITECT hsTnI is not available for use in the U.S. i-STAT TnI-Nx product is in development and not available for sale.