Successful TRAPID-AMI trial for cardiac troponin T high-sensitivity test published in Annals of Emergency Medicine- Roche

The TRAPID-AMI is a prospective observational study supported by Roche and investigated more than 1,200 patients with acute chest pain during 2011-2014. The study was conducted in twelve institutions from nine countries and three continents, led by Professors Christian Mueller, University of Basel (Switzerland), and Bertil Lindahl, University of Uppsala (Sweden). It is the first clinical trial validating a short diagnostic procedure constructed from two blood tests taken from the patient one hour apart in early chest pain patients (i.e. with a pain onset of maximum 6 hours since hospital entry). This new approach was proposed in the earlier APACE trial on patients with later presentation. The TRAPID-AMI study results demonstrate that the new diagnostic procedure shortens the time to diagnose heart attack to one hour from three hours or more, enabling healthcare professionals to treat the majority of patients much earlier as recommended in the new guidelines (2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation).

Results from the TRAPID-AMI1 clinical study have been published online by the Annals of Emergency Medicine, confirming a novel approach for a more rapid diagnosis of heart attack in patients with acute chest pain. The strategy is based on the cardiac troponin T high-sensitivity test from Roche and reduces the observation time needed to rule-in or rule-out a heart attack from 3-6 hours to just 1 hour. It is well established that a fast and reliable diagnosis of heart attack is critical because every hour of delay from the onset of symptoms to treatment increases the mortality risk.