Mini Med 530 G retrospective analysis shows reduction of hypoglycemia published in Diabetes Technology & Therapeutics.-Medtronic

Medtronic plc announced results of a retrospective analysis based on real-world data from over 20,000 MiniMed� 530G users, which found that the pump's Threshold Suspend feature reduced hypoglycemia, especially at night, without significantly increasing hyperglycemia. The results, titled "Retrospective Analysis of the Real-World Use of the Threshold Suspend Feature of Sensor-Augmented Insulin Pumps," were published online, ahead of print, in Diabetes Technology & Therapeutics. The MiniMed 530G system is the first and only system to offer Threshold Suspend, which suspends insulin delivery for up to two hours when the sensor glucose value reaches a pre-set low level and if the user is unable to respond to the Threshold Suspend alarm.

Results of the analysis include: Overall hypoglycemia was reduced by 69 percent: Patient-days where the Threshold Suspend feature was enabled showed 69 percent less time in hypoglycemia (sensor glucose values <=50 mg dl) compared to patient-days when the feature was not enabled (0.64% vs. 2.09%, respectively, p><0.001). night-time hypoglycemia was reduced by 73 percent: the reduction in hypoglycemia seen on threshold suspend-enabled days was more pronounced during nighttime than during daytime hours. a 73 percent reduction in time in hypoglycemia occurring at night was seen on patient-days when the threshold suspend feature was on (percent of sensor glucose values><=50 mg dl, sensor glucose percentages equivalent to 17 minutes night when threshold suspend was off vs. 5 min night for when threshold suspend was on, p><0.001).>

These results are similar to outcomes observed in the ASPIRE In-Home study, which was published in The New England Journal of Medicine in July of 2013.

Comment:The MiniMed integrated system, uses the Threshold Suspend feature and is the first of its kind before the FDA designed to detect dangerous levels of blood sugar and then automatically adjust or shut off to correct the problem.