Disease Awareness

Migraine is the most prevalent neurological disorder worldwide. The symptoms associated with migraine are often disabling in nature, and consequently the condition has a large socioeconomic impact (International Headache Society, 2013; Deen et al., 2017).

This section of the Knowledge Centre covers all aspects of migraine disease awareness, including epidemiology, proposed pathophysiology, presenting symptoms and the diagnostic process. Current and future treatments for migraine, as well as existing guidelines for management of the condition are featured in subsequent sections.

Choose one of the disease awareness sub-sections listed below, or scroll down the page, to learn more.

Epidemiology

Epidemiology

Migraine is highly prevalent worldwide and is associated with social, economic and personal burden and ranks among the 10 leading causes for Years Lived with Disability (YLDs) worldwide. More details in the Epidemiology section for lost days, sleep disturbance and poor HRQoL.

Pathophysiology

Pathophysiology

Proposed pathophysiological mechanisms causing migraine include neurovascular disorder where the trigeminal system is involved. Discover more about the role of the calcitonin gene-related peptide (CGRP) plays in migraine pathology and pain perception.

Symptoms

Symptoms

Symptoms vary widely in patients and often change over the course of an attack. Find out about the prodromal, aura, headache and postdrome phases of migraine and see an fMRI visualisation of cortical spreading depression corresponding with aura.

Diagnosis

Diagnosis

Diagnosing migraine can be difficult: medical history, neurological assessment and exclusion of other causes by assessing pain type, headache location, duration, frequency and demographics. Migraine can then be classified by ICHD-3 criteria.