• What causes migraine pain?

    The brain lacks nociceptors, but they are present in the dura and pia of the meninges.
    View the basis of migraine and the role of the TGVS and its release of neuropeptides that can induce neurogenic inflammation.

  • The burden of migraine

    The migraine epidemiology section features facts, figures and the latest research highlighting the socioeconomic impact of migraine worldwide.

  • Future treatments

    Discover insights into the latest therapeutic developments for migraine including the advances in small molecule and monoclonal antibody therapies.

  • What do the guidelines say?

    Leading national and international guidelines from AAN, EHS, BASH and more, outlining best practice for the management of migraine patients worldwide.

 

Migraine Knowledge Centre

Welcome to the Migraine Knowledge Centre. Migraine is classified by the International Headache Society as one of the four primary headache disorders and has several different treatment options. With no biomarkers or medical tests available, diagnosis of migraine can be a lengthy process, yet receiving the right treatment and care is of paramount importance to patients suffering from the disabling symptoms associated with this neurological condition. 

The Migraine Knowledge Centre contains the latest recommendations for all aspects of patient care, including diagnosis, acute and preventive migraine treatment options, as well as insights into the novel treatments currently in development.

Disease Awareness

Disease Awareness

Discover detailed migraine awareness with/without aura, HALT index, pathophysiology and the trigeminal system, symptoms including visual disturbances and nausea and diagnosis from the International Classification of Headache Disorders 3 (ICHD-3).

Treatment

Treatment

Discover acute and preventive migraine treatment options following the AAN and AHS guidelines that include NSAIDs, triptans, ergotamine derivatives, opioids, beta-blockers, calcium channel blockers and tricyclic antidepressants. Future treatments detail CGRP antagonists.

Guidelines

Guidelines

National and international guidelines on all aspects of migraine management including the European Headache Federation (EHF), the European Federation of Neurological Sciences (EFNS) and the International Headache Society (IHS).

Glossary

Glossary

Review the terms used in the Migraine Knowledge Centre, along with their definitions including cortical spreading depression, Headache-Attributed Lost Time index (HALT), Hemiplegic migraine and vagus nerve stimulation.

Events

Events

Consult the events calendar for upcoming scientific meetings relevant to migraine and follow links to event websites, featuring the American Academy of Neurology, the American Headache Society and the Migraine Trust International Symposium.


 

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