This site is intended for healthcare professionals
Journals
  • Home
  • /
  • Journals
  • /
  • Diabetes
  • /
  • Body Composition Profiling in the UK Biobank Imagi...
Journal

Body Composition Profiling in the UK Biobank Imaging Study.

Read time: 1 mins
Published:21st May 2018
Author: Linge J, Borga M, West J, Tuthill T, Miller MR, Dumitriu A et al.
Availability: Pay for access, or by subscription
Ref.:Obesity (Silver Spring). 2018.
DOI:10.1002/oby.22210

Objective: This study aimed to investigate the value of imaging-based multivariable body composition profiling by describing its association with coronary heart disease (CHD), type 2 diabetes (T2D), and metabolic health on individual and population levels.

Methods: The first 6,021 participants scanned by UK Biobank were included. Body composition profiles (BCPs) were calculated, including abdominal subcutaneous adipose tissue, visceral adipose tissue (VAT), thigh muscle volume, liver fat, and muscle fat infiltration (MFI), determined using magnetic resonance imaging. Associations between BCP and metabolic status were investigated using matching procedures and multivariable statistical modeling.

Results: Matched control analysis showed that higher VAT and MFI were associated with CHD and T2D (P < 0.001). Higher liver fat was associated with T2D (P < 0.001) and lower liver fat with CHD (P < 0.05), matching on VAT. Multivariable modeling showed that lower VAT and MFI were associated with metabolic health (P < 0.001), and liver fat was nonsignificant. Associations remained significant adjusting for sex, age, BMI, alcohol, smoking, and physical activity.

Conclusions: Body composition profiling enabled an intuitive visualization of body composition and showed the complexity of associations between fat distribution and metabolic status, stressing the importance of a multivariable approach. Different diseases were linked to different BCPs, which could not be described by a single fat compartment alone.

 

Read abstract on library site

Access full article