Latest news articles

Added 11 days ago Drug news

FDA advisory committee does not recommend oxycodegol ( NKTR 181) as a treatment for chronic pain and the drug is withdrawn.- Nektar Therapeutics

Nektar Therapeutics issued a statement following a meeting of the FDA's Anesthetic and Analgesic Drug Products Advisory Committee (AADPAC) and...

Added 13 days ago Drug news

MIRROR open-label study of Krystexxa shows response in gout.- Horizon Therapeutics

Horizon Therapeutics announced topline results from its MIRROR open-label study in which methotrexate with Krystexxa (pegloticase injection) provided an increased...

Added 18 days ago Drug news

Health Canada approves Rinvoq for treatment of rheumatoid arthritis patients who have had an inadequate response or intolerance to methotrexate (MTX).- AbbVie

AbbVie announced that Health Canada has approved Rinvoq (upadacitinib) for the treatment of adults with moderately to severely active rheumatoid...

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Learning Zones

An epgonline.org Learning Zone (LZ) is an area of the site dedicated to providing detailed self-directed medical education about a disease, condition or procedure.

Idiopathic Pulmonary Fibrosis

Idiopathic Pulmonary Fibrosis

Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive fibrotic interstitial lung disease that occurs mostly in older adults, is limited to the lungs and often displays a characteristic imaging and histological appearance. Find out how to diagnose IPF and the latest interventions available for patients living with this burden.

Chronic Lymphocytic Leukaemia (CLL)

Chronic Lymphocytic Leukaemia (CLL)

Refine your knowledge of chronic lymphocytic leukaemia (CLL) with information on pathophysiology, diagnosis, treatment options and more

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Transplantation

Transplantation

See information on best practice in solid organ transplantation, and expert discussions on related hot topics.

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Guidelines

Biosimilars in the EU - Information guide for healthcare professionals

This guide has therefore been prepared with the important objective of providing healthcare professionals with reference information on both the science and regulation underpinning the use of biosimilars.

Added 6 days ago

NRAS position paper on biosimilar medicines – Updated February, 2019

In this position paper we set out our recommendations for a national best practice approach to be taken.

Added 6 days ago

Rheumatoid arthritis in adults: management

This guideline covers diagnosing and managing rheumatoid arthritis. It aims to improve quality of life by ensuring that people with rheumatoid arthritis have the right treatment to slow the progression of their condition and control their symptoms.

Added 10 years ago

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Journal articles

A randomised, double-blind, phase III study comparing SB2, an infliximab biosimilar, to the infliximab reference product Remicade in patients with moderate to severe rheumatoid arthritis despite methotrexate therapy.

Objectives: To compare the efficacy, safety, immunogenicity and pharmacokinetics (PK) of SB2 to the infliximab reference product (INF) in patients with moderate to severe rheumatoid arthritis (RA) despite methotrexate therapy.

Added 6 days ago

A phase III randomized study to evaluate the efficacy and safety of CT-P13 compared with reference infliximab in patients with active rheumatoid arthritis: 54-week results from the PLANETRA study.

Background: CT-P13 (Remsima®, Inflectra®) is a biosimilar of the infliximab reference product (RP; Remicade®). The aim of this study was to compare the 54-week efficacy, immunogenicity, safety, pharmacokinetics (PK)...

Added 6 days ago

Efficacy and safety of switching from reference infliximab to CT-P13 compared with maintenance of CT-P13 in ankylosing spondylitis: 102-week data from the PLANETAS extension study.

Objectives: To investigate the efficacy and safety of switching from infliximab reference product (RP) to its biosimilar or maintaining biosimilar treatment in patients with ankylosing spondylitis (AS).

Added 6 days ago

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Clinical trials

Study of Cingal™ for the Relief of Knee Osteoarthritis Compared to Triamcinolone Hexacetonide

This is a multi-center, randomized, double-blind, parallel group, active comparator controlled trial to evaluate the efficacy and safety of a single injection of Cingal for the relief of joint pain in subjects with OA of the knee.

Added 1 year ago

A Study of Ixekizumab (LY2439821) in TNF Inhibitor Experienced Participants With Radiographic Axial Spondyloarthritis (COAST-W)

The main purpose of this study is to evaluate the efficacy and safety of ixekizumab in tumor necrosis factor (TNF) inhibitor-experienced participants with radiographic axial spondyloarthritis (rad-axSpA).

Added 1 year ago

A Study Comparing Upadacitinib (ABT-494) Monotherapy to Methotrexate (MTX) Monotherapy in Adults With Rheumatoid Arthritis (RA) Who Have an Inadequate Response to MTX (SELECT-MONOTHERAPY)

The study objective of Period 1 of this study is to compare the safety and efficacy (signs and symptoms) of upadacitinib 30 mg once daily (QD) alone and 15 mg QD alone versus continuing MTX alone adults with moderately to severely active...

Added 14 days ago

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Blog Posts

Lisa Lishman

EULAR 2018 – Biosimilars: the future of rheumatology?

Posted 1 year ago

EULAR's Annual European Congress of Rheumatology aims to encourage innovation and collaboration across all aspects of rheumatology, something that is particularly well illustrated by biologics and their more affordable counterpart, biosimilars. Could they unlock the door to accessible, life-changing treatment for millions more?

Lauren McCracken

EAACI hot topics: Allergen specific immunotherapy (AIT)

Posted 1 year ago

When should AIT be used to treat your patients with allergies? Is it right for every allergy? And do we really know the long-term effects of this treatment? This blog highlights some of the talking points surrounding AIT discussed at this year’s EAACI Congress.

Hugh Harvey

Metrics Madness

Posted 4 years ago

You shouldn't judge a book by its cover. That much is true, but it's also common sense not to judge a book by measuring the whiteness of its pages, or the amount of hamsters you can place on it. So why do we measure the fabulous NHS with nonsense metrics?

CME

Shoulder examination and diagnosis

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10 minute consultation: Plantar heel pain

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Breaking bad news: a how to do it guide

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